Reactome | UBR1 [cytosol]

UBR1 [cytosol]

Stable Identifier

R-HSA-976040

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase UBR1, UBR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IWV7 UBR1

Gene Names

UBR1

Chain

initiator methionine:, chain:2-1749

Reference Genes

BioGPS Gene:197131 UBR1

COSMIC (genes):UBR1 UBR1

CTD Gene:197131 UBR1

dbSNP Gene:197131 UBR1

ENSEMBL:ENSG00000159459 UBR1

HGNC:16808 UBR1

KEGG:hsa:197131 UBR1

Monarch:197131 UBR1

NCBI Gene:197131 UBR1

OMIM:605981 UBR1

UCSC:Q8IWV7 UBR1

Reference Transcript

RefSeq:NM_174916.2 UBR1

Other Identifiers

11720726_at

11720727_at

11720728_at

16807996

197131

226921_PM_at

226921_at

238528_PM_at

238528_at

3620882

3620883

3620884

3620885

3620886

3620887

3620888

3620889

3620890

3620892

3620895

3620896

3620897

3620898

3620899

3620900

3620901

3620902

3620903

3620904

3620905

3620906

3620907

3620908

3620909

3620910

3620911

3620912

3620913

3620915

3620916

3620917

3620918

3620919

3620920

3620921

3620922

3620923

3620924

3620925

3620927

3620928

3620929

3620930

3620931

3620932

3620933

3620934

3620935

3620936

3620937

3620938

3620939

3620940

3620941

3620942

3620944

3620946

3620947

3620948

3620950

3620951

3620952

3620953

3620957

44128_at

48354_at

7987981

A_23_P152066

A_23_P300770

A_24_P102203

GE87037

GE87038

GO:0000151

GO:0000502

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0008270

GO:0016567

GO:0016740

GO:0030163

GO:0032007

GO:0043161

GO:0046872

GO:0061630

GO:0070728

GO:0071233

GO:0071596

GO:0140096

HMNXSV003002728

Hs.28113.0.A1_3p_at

Hs.293477.0.A1_3p_at

ILMN_1795964

PH_hs_0022597

TC15001271.hg

TC15002506.hg

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

UBR1 [cytosol] (Bos taurus)

UBR1 [cytosol] (Canis familiaris)

UBR1 [cytosol] (Gallus gallus)

UBR1 [cytosol] (Mus musculus)

UBR1 [cytosol] (Saccharomyces cerevisiae)

UBR1 [cytosol] (Sus scrofa)

ubr11 [cytosol] (Schizosaccharomyces pombe)

ubr-1 [cytosol] (Caenorhabditis elegans)

ubr1 [cytosol] (Schizosaccharomyces pombe)

ubr1 [cytosol] (Xenopus tropicalis)

Homologues of UBR1 [cytosol] (Saccharomyces cerevisiae)

Homologues of UBR1 [cytosol] (Schizosaccharomyces pombe)

UBR2 [cytosol] (Saccharomyces cerevisiae)

Ubr1 [cytosol] (Drosophila melanogaster)

Ubr1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_777576.1

ENSEMBL

ENSP00000290650, ENST00000290650

OpenTargets

ENSG00000159459

IntEnz

2.3.2.27

HPA

ENSG00000159459-UBR1

PRO

Q8IWV7

Pharos - Targets

Q8IWV7

GlyGen

Q8IWV7

Orphanet

UBR1

HMDB Protein

HMDBP09268

PDB

3NY1, 5TDC

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06850 CRH	1	CRH [extracellular region] (R-HSA-420146)	0.564	2
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.553	2
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.527	2
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.527	4
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.527	2
UniProt:Q08495 DMTN	1	DMTN [cytosol] (R-HSA-5216222)	0.527	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.527	4
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.527	2
UniProt:P24387 CRHBP	1	CRHBP [extracellular region] (R-HSA-8937598)	0.527	2
UniProt:Q9BY77 POLDIP3	2	POLDIP3 [cytosol] (R-HSA-8850627) POLDIP3 [nucleoplasm] (R-HSA-8850646)	0.499	2