Reactome | IGF2 [extracellular region]

Hemostasis (Sus scrofa)

- Platelet activation, signaling and aggregation (Sus scrofa)
  - Response to elevated platelet cytosolic Ca2+ (Sus scrofa)
    - Platelet degranulation (Sus scrofa)
      - Exocytosis of platelet alpha granule contents (Sus scrofa)
        
        Platelet alpha granule contents [extracellular region] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Sus scrofa)
  - IGFBP1 binds IGF forming IGF:IGFBP1 (Sus scrofa)
    - IGF1,2 [extracellular region] (Sus scrofa)
      - Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
    - IGF:IGFBP1 [extracellular region] (Sus scrofa)
      - IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
  - IGFBP2 binds IGF forming IGF:IGFBP2 (Sus scrofa)
    - IGF1,2 [extracellular region] (Sus scrofa)
      - Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
    - IGF:IGFBP2 [extracellular region] (Sus scrofa)
      - IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
  - IGFBP4 binds IGF forming IGF:IGFBP4 (Sus scrofa)
    - IGF1,2 [extracellular region] (Sus scrofa)
      - Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
    - IGF:IGFBP4 [extracellular region] (Sus scrofa)
      - IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
  - IGFBP6 binds IGF forming IGF:IGFBP6 (Sus scrofa)
    - IGF1,2 [extracellular region] (Sus scrofa)
      - Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
    - IGF:IGFBP6 [extracellular region] (Sus scrofa)
      - IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
  - PAAP-A proteolyzes IGF:IGFBP4 (Sus scrofa)
    - IGF1,2 [extracellular region] (Sus scrofa)
      - Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
    - IGF:IGFBP4 [extracellular region] (Sus scrofa)
      - IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
    - IGF1,2 binds IGF1R (Sus scrofa)
      - IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
      - IGF1,2:IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
    - IGF1,2:IGF1R autophosphorylates (Sus scrofa)
      - IGF1,2:IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
      - IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
    - IGF1R signaling cascade (Sus scrofa)
      - IRS-related events triggered by IGF1R (Sus scrofa)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-IGF1R:IRS1,4 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-IGF1R:IRS2 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Sus scrofa)
        
        IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
      - SHC-related events triggered by IGF1R (Sus scrofa)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1R phosphorylates SHC1 (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        p-3Y-SHC1 dissociates from IGF1R (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Sus scrofa)
        
        IGF1,2:p-3Y-IGF1R [plasma membrane] (Sus scrofa)
        
        IGF1,2 [extracellular region] (Sus scrofa)
        
        Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)
        
        IGF2 [extracellular region] (Sus scrofa)