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TLR4 [endosome membrane]
Stable Identifier
R-HSA-2201285
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Auto-ubiquitination of TRAF3 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
OPTN binds TBK1 within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TBK1 is phosphorylated within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRIF-mediated programmed cell death (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
RIP3 binds TRIF to mediate necroptosis (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRIF:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TLR4-induced ripoptosome assembly (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
TLR4 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00206 TLR4
Gene Names
TLR4
Chain
signal peptide:1-23, chain:24-839
Reference Genes
BioGPS Gene:7099 TLR4
COSMIC (genes):TLR4 TLR4
CTD Gene:7099 TLR4
dbSNP Gene:7099 TLR4
ENSEMBL:ENSG00000136869 TLR4
HGNC:11850 TLR4
KEGG:hsa:7099 TLR4
Monarch:7099 TLR4
NCBI Gene:7099 TLR4
OMIM:603030 TLR4
UCSC:O00206 TLR4
Reference Transcript
RefSeq:NM_138554.4 TLR4
RefSeq:NM_138557.2 TLR4
RefSeq:NM_003266.3 TLR4
Participates
as a component of
TLR4:LY96 [endosome membrane] (Homo sapiens)
Other forms of this molecule
2xN4GlycoAsn-TLR4 [plasma membrane]
Inferred To
TLR4 [endosome membrane]
(Bos taurus)
TLR4 [endosome membrane]
(Canis familiaris)
TLR4 [endosome membrane]
(Gallus gallus)
TLR4 [endosome membrane]
(Sus scrofa)
Tlr4 [endosome membrane]
(Mus musculus)
Tlr4 [endosome membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_003257.1
,
NP_612567.1
,
NP_612564.1
Guide to Pharmacology - Targets
1754
OpenTargets
ENSG00000136869
ENSEMBL
ENSG00000136869
,
ENST00000394487
,
ENSP00000363089
,
ENSP00000377997
,
ENST00000355622
ZINC - Substances
TLR4_HUMAN
ZINC target
O00206
PRO
O00206
GlyGen
O00206
PDB
3UL9
,
2Z65
,
3FXI
,
8WO1
,
2Z66
,
5NAM
,
2Z62
,
8WTA
,
2Z63
,
5NAO
,
3UL8
,
3ULA
,
3UL7
,
4G8A
ZINC - Investigational
TLR4_HUMAN
HPA
ENSG00000136869-TLR4
GeneCards
TLR4
Pharos - Targets
O00206
Orphanet
TLR4
ZINC - Predictions - Purchasable
TLR4_HUMAN
HMDB Protein
HMDBP02639
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P58753 TIRAP
2
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
TIRAP [cytosol]
(R-HSA-166141)
0.807
6
UniProt:Q99836 MYD88
8
MYD88 [cytosol]
(R-HSA-166059)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [endosome membrane]
(R-HSA-975123)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 R196C [cytosol]
(R-HSA-5602329)
0.758
4
UniProt:Q9Y6Y9 LY96
3
LY96 [extracellular region]
(R-HSA-9707658)
LY96 [endosome membrane]
(R-HSA-2201307)
2xN4GlycoAsn-LY96 [plasma membrane]
(R-HSA-166047)
0.743
7
UniProt:O00206 TLR4
2
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
TLR4 [endosome membrane]
(R-HSA-2201285)
0.692
3
UniProt:Q9NPH5 NOX4
2
NOX4 [endoplasmic reticulum membrane]
(R-HSA-6807561)
NOX4 [plasma membrane]
(R-HSA-5212694)
0.683
4
UniProt:Q86XR7 TICAM2
3
MyrG-p-S16-TICAM2 [secretory granule membrane]
(R-HSA-6804964)
MyrG-p-S16-TICAM2 [plasma membrane]
(R-HSA-166160)
MyrG-p-S16-TICAM2 [endosome membrane]
(R-HSA-2201336)
0.678
3
UniProt:P09429 HMGB1
5
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
HMGB1 [nucleoplasm]
(R-HSA-266221)
HMGB1 [extracellular region]
(R-HSA-879382)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
0.604
3
UniProt:P11226 MBL2
1
MBL2 [extracellular region]
(R-HSA-166674)
0.558
2
UniProt:O43699-3 SIGLEC6
0.544
2
UniProt:O15389 SIGLEC5
4
SIGLEC5 [ficolin-1-rich granule membrane]
(R-HSA-6801283)
SIGLEC5 [secretory granule membrane]
(R-HSA-6801292)
SIGLEC5 [plasma membrane]
(R-HSA-197711)
SIGLEC5 [tertiary granule membrane]
(R-HSA-6801320)
0.544
2
UniProt:Q9Y336 SIGLEC9
2
SIGLEC9 [plasma membrane]
(R-HSA-197723)
SIGLEC9 [secretory granule membrane]
(R-HSA-6804775)
0.544
2
UniProt:Q9Y2C9 TLR6
1
TLR6 [plasma membrane]
(R-HSA-168061)
0.499
2
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