Reactome | SIGLEC5 [secretory granule membrane]

SIGLEC5 [secretory granule membrane]

Stable Identifier

R-HSA-6801292

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

Sialic acid binding Ig-like lectin 5 precursor, SIL5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15389 SIGLEC5

Gene Names

SIGLEC5, CD33L2, OBBP2

Chain

signal peptide:1-16, chain:17-551

Reference Genes

BioGPS Gene:8778 SIGLEC5

COSMIC (genes):SIGLEC5 SIGLEC5

CTD Gene:8778 SIGLEC5

dbSNP Gene:8778 SIGLEC5

ENSEMBL:ENSG00000268500.7 SIGLEC5

HGNC:10874 SIGLEC5

KEGG Gene (Homo sapiens):8778 SIGLEC5

Monarch:8778 SIGLEC5

NCBI Gene:8778 SIGLEC5

OMIM:604200 SIGLEC5

UCSC:O15389 SIGLEC5

Reference Transcript

RefSeq:NM_003830.3 SIGLEC5

Other Identifiers

0006220139

11729739_at

16874911

220000_PM_at

220000_at

3839678

3869155

3869157

3869159

3869160

3869161

3869165

3869166

3869167

3869168

3869169

3869170

3869171

3869172

3869173

3869174

3869175

3869176

3869192

3869193

3869194

8038877

8778

90196_at

A_24_P48539

GE58313

GO:0005515

GO:0005622

GO:0005737

GO:0005886

GO:0007155

GO:0016020

GO:0016021

GO:0030246

GO:0030667

GO:0031410

GO:0033691

GO:0043226

GO:0070821

GO:0101003

HMNXSV003018737

HMNXSV003031195

ILMN_1652381

ILMN_1740298

PH_hs_0006411

TC19001784.hg

g4502658_3p_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

SIGLEC5 [tertiary granule membrane]

SIGLEC5 [plasma membrane]

SIGLEC5 [ficolin-1-rich granule membrane]

Inferred To

LOC101884775 [secretory granule membrane] (Danio rerio)

LOC103910452 [secretory granule membrane] (Danio rerio)

XB5961956 [secretory granule membrane] (Xenopus tropicalis)

meis1 [secretory granule membrane] (Xenopus tropicalis)

Homologues of SIGLEC5 [secretory granule membrane] (Danio rerio)

Homologues of SIGLEC5 [secretory granule membrane] (Xenopus tropicalis)

SIGLEC5 [secretory granule membrane] (Canis familiaris)

SIGLEC5 [secretory granule membrane] (Danio rerio)

SIGLEC5 [secretory granule membrane] (Xenopus tropicalis)

LOC112442215 [secretory granule membrane] (Bos taurus)

siglecl1 [secretory granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003821.1

OpenTargets

ENSG00000105501

GeneCards

O15389

HPA

ENSG00000105501-SIGLEC5

Ensembl

ENST00000683636, ENSG00000268500, ENSP00000507738

PRO

O15389

Pharos - Targets

O15389

Orphanet

24901

HMDB Protein

HMDBP14227

PDB

2ZG3, 2ZG2, 2ZG1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.544	2