Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SIGLEC5 [secretory granule membrane]
Stable Identifier
R-HSA-6801292
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Synonyms
Sialic acid binding Ig-like lectin 5 precursor, SIL5_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
SIGLEC5 [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15389 SIGLEC5
Gene Names
SIGLEC5, CD33L2, OBBP2
Chain
signal peptide:1-16, chain:17-551
Reference Genes
BioGPS Gene:8778 SIGLEC5
COSMIC (genes):SIGLEC5 SIGLEC5
CTD Gene:8778 SIGLEC5
dbSNP Gene:8778 SIGLEC5
ENSEMBL:ENSG00000268500 SIGLEC5
HGNC:10874 SIGLEC5
KEGG:hsa:8778 SIGLEC5
Monarch:8778 SIGLEC5
NCBI Gene:8778 SIGLEC5
OMIM:604200 SIGLEC5
UCSC:O15389 SIGLEC5
Reference Transcript
RefSeq:NM_003830.3 SIGLEC5
Other Identifiers
11729739_at
16874911
220000_PM_at
220000_at
3839678
3869155
3869157
3869159
3869160
3869161
3869165
3869166
3869167
3869168
3869169
3869170
3869171
3869172
3869173
3869174
3869175
3869176
3869192
3869193
3869194
8038877
8778
90196_at
A_24_P48539
GE58313
GO:0005515
GO:0005886
GO:0007155
GO:0016020
GO:0030246
GO:0030667
GO:0033691
GO:0070821
GO:0101003
HMNXSV003018737
HMNXSV003031195
ILMN_1652381
ILMN_1740298
PH_hs_0006411
TC19001784.hg
g4502658_3p_at
Participates
as a member of
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
Other forms of this molecule
SIGLEC5 [tertiary granule membrane]
SIGLEC5 [plasma membrane]
SIGLEC5 [ficolin-1-rich granule membrane]
Inferred To
siglecl2 [secretory granule membrane]
(Xenopus tropicalis)
XB5961956 [secretory granule membrane]
(Xenopus tropicalis)
Homologues of SIGLEC5 [secretory granule membrane]
(Xenopus tropicalis)
SIGLEC5 [secretory granule membrane]
(Bos taurus)
SIGLEC5 [secretory granule membrane]
(Sus scrofa)
LOC476396 [secretory granule membrane]
(Canis familiaris)
mag [secretory granule membrane]
(Danio rerio)
Cross References
ENSEMBL
ENST00000683636
,
ENSP00000507738
OpenTargets
ENSG00000105501
HPA
ENSG00000268500-SIGLEC5
PRO
O15389
Pharos - Targets
O15389
GlyGen
O15389
HMDB Protein
HMDBP14227
PDB
2ZG3
,
2ZG2
,
2ZG1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00206 TLR4
2
TLR4 [endosome membrane]
(R-HSA-2201285)
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
0.544
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text