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MyrG-p-S16-TICAM2 [endosome membrane]
Stable Identifier
R-HSA-2201336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
TRAM
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
Endocytosis of TRAM (TICAM2) (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Auto-ubiquitination of TRAF3 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
OPTN binds TBK1 within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TBK1 is phosphorylated within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRIF-mediated programmed cell death (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
RIP3 binds TRIF to mediate necroptosis (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRIF:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TLR4-induced ripoptosome assembly (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86XR7 TICAM2
Gene Names
TICAM2, TIRAP3, TIRP, TRAM
Chain
initiator methionine:, chain:2-235
Reference Genes
BioGPS Gene:100302736 TICAM2
BioGPS Gene:353376 TICAM2
COSMIC (genes):TICAM2 TICAM2
CTD Gene:100302736 TICAM2
CTD Gene:353376 TICAM2
dbSNP Gene:100302736 TICAM2
dbSNP Gene:353376 TICAM2
ENSEMBL:ENSG00000243414 TICAM2
ENSEMBL_homo_sapiens_GENE:ENSG00000243414.6 TICAM2
HGNC:21354 TICAM2
KEGG Gene (Homo sapiens):100302736 TICAM2
KEGG Gene (Homo sapiens):353376 TICAM2
Monarch:100302736 TICAM2
Monarch:353376 TICAM2
NCBI Gene:100302736 TICAM2
NCBI Gene:353376 TICAM2
OMIM:608321 TICAM2
UCSC:Q86XR7 TICAM2
Reference Transcript
RefSeq:NM_021649.7 TICAM2
RefSeq:NM_001164468.3 TICAM2
RefSeq:NM_001164469.3 TICAM2
Other Identifiers
11730553_a_at
11745544_a_at
11758448_s_at
228234_PM_at
228234_at
239431_PM_at
239431_at
2871828
2871829
2871830
2871831
2871832
2871833
2871834
2871835
2871836
2871837
2871846
2871847
2871848
2871849
353376
61865_at
85251_at
A_33_P3327270
GE62694
GO:0001891
GO:0002376
GO:0002735
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005886
GO:0006909
GO:0006954
GO:0007165
GO:0010008
GO:0016020
GO:0016192
GO:0019901
GO:0023052
GO:0030667
GO:0031410
GO:0031663
GO:0031901
GO:0031902
GO:0032481
GO:0032816
GO:0034142
GO:0034145
GO:0035666
GO:0035669
GO:0042995
GO:0043123
GO:0043226
GO:0043330
GO:0045087
GO:0060090
GO:0071222
GO:0071651
GO:0098542
GO:1900017
GO:2000494
HMNXSV003015098
Hs.114055.0.A1_3p_at
Hs.184418.0.A1_3p_at
ILMN_1651346
PH_hs_0034823
Participates
as an input of
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
as an output of
Endocytosis of TRAM (TICAM2) (Homo sapiens)
as a component of
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Other forms of this molecule
MyrG-p-S16-TICAM2 [plasma membrane]
MyrG-p-S16-TICAM2 [secretory granule membrane]
Inferred To
phospho-ticam1 [endosome membrane]
(Danio rerio)
phospho-Ticam2 [endosome membrane]
(Mus musculus)
phospho-Ticam2 [endosome membrane]
(Rattus norvegicus)
Ghost homologue of MyrG-p-S16-TICAM2 [endosome membrane]
(Gallus gallus)
phospho-TICAM2 [endosome membrane]
(Bos taurus)
phospho-TICAM2 [endosome membrane]
(Canis familiaris)
phospho-TICAM2 [endosome membrane]
(Sus scrofa)
Modified Residues
Name
N-myristoylglycine at 2
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Name
O-phospho-L-serine at 16
Coordinate
16
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_067681.1
,
NP_001157940.1
,
NP_001157941.1
OpenTargets
ENSG00000243414
GeneCards
Q86XR7
HPA
ENSG00000243414-TICAM2
Ensembl
ENSP00000415139
,
ENSG00000243414
,
ENST00000427199
PRO
Q86XR7
Pharos - Targets
Q86XR7
PDB
2M1W
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00206 TLR4
2
TLR4 [endosome membrane]
(R-HSA-2201285)
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
0.678
3
UniProt:Q6SZW1 SARM1
0.592
2
UniProt:P50222 MEOX2
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:P0C6I1-PRO_0000324727 C
0.463
2
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