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NOX4 [plasma membrane]
Stable Identifier
R-HSA-5212694
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NADPH oxidase 4 ecNumber1.6.3.-/ecNumber, NOX4_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)
NOX4 [plasma membrane] (Homo sapiens)
FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)
NOX4 [plasma membrane] (Homo sapiens)
Signaling by FLT3 fusion proteins (Homo sapiens)
FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)
NOX4 [plasma membrane] (Homo sapiens)
FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)
NOX4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPH5 NOX4
Gene Names
NOX4, RENOX
Chain
chain:1-578
Reference Genes
BioGPS Gene:50507 NOX4
COSMIC (genes):NOX4 NOX4
CTD Gene:50507 NOX4
dbSNP Gene:50507 NOX4
ENSEMBL:ENSG00000086991 NOX4
HGNC:7891 NOX4
KEGG Gene (Homo sapiens):50507 NOX4
Monarch:50507 NOX4
NCBI Gene:50507 NOX4
OMIM:605261 NOX4
UCSC:Q9NPH5 NOX4
Reference Transcript
RefSeq:XM_011542857.2 NOX4
RefSeq:NM_001300995.1 NOX4
RefSeq:NM_001143836.2 NOX4
RefSeq:NM_016931.4 NOX4
RefSeq:NM_001291926.1 NOX4
RefSeq:NM_001143837.1 NOX4
RefSeq:NM_001291927.1 NOX4
Other Identifiers
0000670279
11731680_a_at
11740475_x_at
11740476_a_at
11741143_x_at
11745102_a_at
11745103_x_at
11750957_s_at
11755736_a_at
16743148
17120580
17120582
17120584
17120586
219773_at
236843_at
3330308
3330310
3330311
3330313
3330314
3330315
3330316
3385952
3385953
3385954
3385955
3385956
3385957
3385958
3385962
3385966
3385967
3385969
3385970
3385971
3385975
3385982
3385983
3385984
3385985
3385986
3385988
3385990
3385991
3385993
3385996
3385998
3385999
3386003
3386004
3386005
3386006
3386007
3386008
50507
55457_at
77936_at
7950933
A_23_P47148
A_33_P3224324
GE762676
GO:0000166
GO:0000902
GO:0001666
GO:0001725
GO:0003013
GO:0003015
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005856
GO:0005886
GO:0005925
GO:0006091
GO:0006259
GO:0006464
GO:0006520
GO:0006790
GO:0006801
GO:0006950
GO:0006952
GO:0006954
GO:0007010
GO:0007165
GO:0007568
GO:0007569
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009055
GO:0009058
GO:0010467
GO:0014911
GO:0016020
GO:0016021
GO:0016174
GO:0016175
GO:0016324
GO:0016491
GO:0019826
GO:0019899
GO:0020037
GO:0022607
GO:0022900
GO:0030054
GO:0030154
GO:0032991
GO:0034599
GO:0034641
GO:0040011
GO:0042554
GO:0042592
GO:0043020
GO:0043065
GO:0043167
GO:0043226
GO:0043406
GO:0044281
GO:0045453
GO:0048471
GO:0048856
GO:0048870
GO:0050660
GO:0050664
GO:0050667
GO:0051496
GO:0051897
GO:0055007
GO:0055114
GO:0061098
GO:0070374
GO:0071320
GO:0071333
GO:0071480
GO:0071560
GO:0071944
GO:0072341
GO:0072593
GO:0097038
GO:1903409
GO:1990782
GO:2000379
GO:2000573
Hs.131188.0.A1_3p_at
ILMN_1735996
ILMN_3251346
PH_hs_0028252
TC11000420.hg
TC11002178.hg
TC11002666.hg
TC11003286.hg
g8393842_3p_at
Participant Of
output
FLT3 ITD- and STAT5-dependent NOX4 gene expression
Other forms of this molecule
NOX4 [endoplasmic reticulum membrane]
Cross References
RefSeq
NP_001278855.1
,
NP_001137309.1
,
XP_011541159.1
,
NP_001287924.1
,
NP_058627.1
,
NP_001278856.1
,
NP_001137308.1
ZINC - World Drugs
NOX4_HUMAN
OpenTargets
ENSG00000086991
ZINC - Substances
NOX4_HUMAN
ZINC target
Q9NPH5
ZINC - Biogenic
NOX4_HUMAN
PRO
Q9NPH5
ZINC - Metabolites
NOX4_HUMAN
HPA
ENSG00000086991-NOX4
GeneCards
Q9NPH5
Ensembl
ENSP00000376961
,
ENST00000263317
,
ENSG00000086991
,
ENSP00000412446
,
ENST00000375979
,
ENSP00000435039
,
ENST00000343727
,
ENSP00000435474
,
ENST00000532825
,
ENSP00000434924
,
ENST00000527956
,
ENST00000529343
,
ENSP00000263317
,
ENST00000393282
,
ENSP00000436892
,
ENSP00000433797
,
ENST00000424319
,
ENSP00000365146
,
ENSP00000344747
,
ENST00000534731
,
ENST00000531342
ZINC - Predictions - Purchasable
NOX4_HUMAN
HMDB Protein
HMDBP08280
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00206 TLR4
2
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
TLR4 [endosome membrane]
(R-HSA-2201285)
0.683
4
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