2xN4GlycoAsn-TLR4 [plasma membrane]

Stable Identifier
R-HSA-166045
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TLR4
Icon
2xN4GlycoAsn-TLR4 [plasma membrane] icon
2xN4GlycoAsn-TLR4 [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
11706042 MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor

Ulevitch, RJ, da Silva Correia, J

J. Biol. Chem. 2002
External Reference Information
External Reference
UniProt:O00206 TLR4
Gene Names
TLR4
Chain
signal peptide:1-23, chain:24-839
Reference Genes
BioGPS Gene:7099 TLR4
COSMIC (genes):TLR4 TLR4
CTD Gene:7099 TLR4
dbSNP Gene:7099 TLR4
ENSEMBL:ENSG00000136869 TLR4
HGNC:11850 TLR4
KEGG:hsa:7099 TLR4
Monarch:7099 TLR4
NCBI Gene:7099 TLR4
OMIM:603030 TLR4
UCSC:O00206 TLR4
Reference Transcript
Participates
as a component of
as an input of
Other forms of this molecule
TLR4 [endosome membrane]
Inferred To
Tehao [plasma membrane] (Drosophila melanogaster)
MstProx [plasma membrane] (Drosophila melanogaster)
Tlr4 [plasma membrane] (Mus musculus)
Tlr4 [plasma membrane] (Rattus norvegicus)
Tl [plasma membrane] (Drosophila melanogaster)
Homologues of 2xN4GlycoAsn-TLR4 [plasma membrane] (Drosophila melanogaster)
Toll-9 [plasma membrane] (Drosophila melanogaster)
TLR4 [plasma membrane] (Bos taurus)
TLR4 [plasma membrane] (Canis familiaris)
TLR4 [plasma membrane] (Gallus gallus)
TLR4 [plasma membrane] (Sus scrofa)
Toll-4 [plasma membrane] (Drosophila melanogaster)
Modified Residues
Name
N4-glycosyl-L-asparagine at 526
Coordinate
526
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Name
N4-glycosyl-L-asparagine at 575
Coordinate
575
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - Substances
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
HPA
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P58753 TIRAP  2 0.807 6
 UniProt:Q99836 MYD88  8 0.758 4
 UniProt:Q9Y6Y9 LY96  3 0.743 7
 UniProt:O00206 TLR4  2 0.692 3
 UniProt:Q9NPH5 NOX4  2 0.683 4
 UniProt:Q86XR7 TICAM2  3 0.678 3
 UniProt:P09429 HMGB1  5 0.604 3
 UniProt:P11226 MBL2  1 0.558 2
 UniProt:O43699-3 SIGLEC6      0.544 2
 UniProt:O15389 SIGLEC5  4 0.544 2
 UniProt:Q9Y336 SIGLEC9  2 0.544 2
 UniProt:Q9Y2C9 TLR6  1 0.499 2
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