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3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2173145
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
3x4Hyp-5Hyl-COL18A1, 4-Hyp 5-Hyl-collagen alpha-1(XVIII) chain, 4-hydroxyprolyl-collagen alpha-1(XVIII) chain, COL18A1, COIA1_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Homo sapiens)
COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Collagen chain trimerization (Homo sapiens)
Association of procollagen type XVIII (Homo sapiens)
C-linked procollagen type XVIII trimer [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)
PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2 (Homo sapiens)
COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)
Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)
Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen triple helix formation (Homo sapiens)
Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagen and procollagen triple helices [endoplasmic reticulum lumen] (Homo sapiens)
Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens)
Collagen type XVIII [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen C-linked trimers [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen type XVIII trimer [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Secretion of collagens (Homo sapiens)
Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagens and tropocollagens [endoplasmic reticulum lumen] (Homo sapiens)
Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens)
Collagen type XVIII [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P39060 COL18A1
Gene Names
COL18A1
Chain
signal peptide:1-23, chain:24-1754, chain:1572-1754, chain:-1754
Reference Genes
BioGPS Gene:80781 COL18A1
COSMIC (genes):COL18A1 COL18A1
CTD Gene:80781 COL18A1
dbSNP Gene:80781 COL18A1
ENSEMBL:ENSG00000182871 COL18A1
HGNC:2195 COL18A1
KEGG:hsa:80781 COL18A1
Monarch:80781 COL18A1
NCBI Gene:80781 COL18A1
OMIM:120328 COL18A1
UCSC:P39060 COL18A1
Reference Transcript
RefSeq:NM_130444.2 COL18A1
RefSeq:NM_130445.3 COL18A1
RefSeq:NM_030582.3 COL18A1
Participates
as a member of
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
as a candidate of
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-COL18A1(?-1754) [extracellular region]
GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
COL18A1(?-1754) [extracellular region]
COL18A1(1572-11754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
GalHyl-COL18A1(24-1754) [extracellular region]
5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-COL18A1(24-1754) [extracellular region]
GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-?) [extracellular region]
5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-?) [extracellular region]
GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-COL18A1(24-?) [extracellular region]
COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-?) [extracellular region]
COL18A1(?-1571) [extracellular region]
5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
Inferred To
Col18a1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
(Mus musculus)
COL18A1 [endoplasmic reticulum lumen]
(Bos taurus)
COL18A1 [endoplasmic reticulum lumen]
(Canis familiaris)
COL18A1 [endoplasmic reticulum lumen]
(Sus scrofa)
Modified Residues
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,5R)-5-hydroxylysine at unknown position
PsiMod Name
(2S,5R)-5-hydroxylysine
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.
Cross References
OpenTargets
ENSG00000182871
ENSEMBL
ENST00000651438
,
ENST00000355480
,
ENSP00000347665
,
ENST00000359759
,
ENSP00000352798
,
ENSG00000182871
,
ENSP00000498485
GeneCards
COL18A1
HPA
ENSG00000182871-COL18A1
PRO
P39060
Pharos - Targets
P39060
GlyGen
P39060
Orphanet
COL18A1
HMDB Protein
HMDBP13479
PDB
3HON
,
1BNL
,
3HSH
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:28304 HEPARIN
0.564
2
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