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3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2172997
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
3x4Hyp-3Hyp-COL18A1, 3,4-hydroxyprolyl-collagen alpha-1(XVIII) chain, COL18A1, COIA1_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)
Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates [endoplasmic reticulum membrane] (Homo sapiens)
Lysyl hydroxylase procollagen substrates [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)
3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P39060 COL18A1
Gene Names
COL18A1
Chain
signal peptide:1-23, chain:24-1754, chain:1572-1754, chain:-1754
Reference Genes
BioGPS Gene:80781 COL18A1
COSMIC (genes):COL18A1 COL18A1
CTD Gene:80781 COL18A1
dbSNP Gene:80781 COL18A1
ENSEMBL:ENSG00000182871 COL18A1
HGNC:2195 COL18A1
KEGG:hsa:80781 COL18A1
Monarch:80781 COL18A1
NCBI Gene:80781 COL18A1
OMIM:120328 COL18A1
UCSC:P39060 COL18A1
Reference Transcript
RefSeq:NM_030582.3 COL18A1
RefSeq:NM_130445.3 COL18A1
RefSeq:NM_001379500.1 COL18A1
RefSeq:NM_130444.2 COL18A1
Participates
as a candidate of
3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-COL18A1(?-1754) [extracellular region]
GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
COL18A1(?-1754) [extracellular region]
COL18A1(1572-11754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
GalHyl-COL18A1(24-1754) [extracellular region]
5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-COL18A1(24-1754) [extracellular region]
GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-?) [extracellular region]
5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-?) [extracellular region]
GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-COL18A1(24-?) [extracellular region]
COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-?) [extracellular region]
COL18A1(?-1571) [extracellular region]
5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
Inferred To
Col18a1 [endoplasmic reticulum lumen]
(Mus musculus)
Col18a1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
emid1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
COL18A1 [endoplasmic reticulum lumen]
(Bos taurus)
COL18A1 [endoplasmic reticulum lumen]
(Canis familiaris)
COL18A1 [endoplasmic reticulum lumen]
(Gallus gallus)
COL18A1 [endoplasmic reticulum lumen]
(Sus scrofa)
Modified Residues
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,3S)-3-hydroxyproline at unknown position
PsiMod Name
(2S,3S)-3-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.
Cross References
RefSeq
NP_001366429.1
,
NP_569712.2
,
NP_085059.2
,
NP_569711.2
OpenTargets
ENSG00000182871
ENSEMBL
ENSP00000347665
,
ENST00000355480
,
ENSP00000352798
,
ENST00000651438
,
ENSG00000182871
,
ENST00000359759
,
ENSP00000498485
GeneCards
COL18A1
HPA
ENSG00000182871-COL18A1
PRO
P39060
Pharos - Targets
P39060
GlyGen
P39060
Orphanet
COL18A1
HMDB Protein
HMDBP13479
PDB
1BNL
,
3HON
,
3HSH
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:28304 HEPARIN
0.564
2
UniProt:P08253 MMP2
5
MMP2(110-660) [extracellular region]
(R-HSA-381456)
MMP2(30-660) [extracellular region]
(R-HSA-1604364)
MMP2(67-660) [extracellular region]
(R-HSA-1604345)
MMP2(30-66) [extracellular region]
(R-HSA-1604347)
MMP2(67-109) [extracellular region]
(R-HSA-1604371)
0.527
2
UniProt:O60568 PLOD3
1
PLOD3 [endoplasmic reticulum membrane]
(R-HSA-1981135)
0.527
4
UniProt:O15460 P4HA2
1
P4HA2 [endoplasmic reticulum lumen]
(R-HSA-2980974)
0.527
3
UniProt:Q6ISS4 LAIR2
1
LAIR2 [extracellular region]
(R-HSA-5696342)
0.527
3
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