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COL18A1(24-1754) [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2172308
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
COL18A1, Collagen alpha-1(XVIII) chain, COIA1_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
Collagen chain trimerization (Homo sapiens)
Association of procollagen type XVIII (Homo sapiens)
C-linked procollagen type XVIII trimer [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
P4HB binds Collagen chains (Homo sapiens)
Collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
P4HB:Collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)
Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates [endoplasmic reticulum membrane] (Homo sapiens)
Lysyl hydroxylase procollagen substrates [endoplasmic reticulum lumen] (Homo sapiens)
Collagen propeptides, chains [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen triple helix formation (Homo sapiens)
Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagen and procollagen triple helices [endoplasmic reticulum lumen] (Homo sapiens)
Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens)
Collagen type XVIII [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen C-linked trimers [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen type XVIII trimer [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Homo sapiens)
P4HB:Collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
Secretion of collagens (Homo sapiens)
Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagens and tropocollagens [endoplasmic reticulum lumen] (Homo sapiens)
Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens)
Collagen type XVIII [endoplasmic reticulum lumen] (Homo sapiens)
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
COL18A1(24-1754) [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P39060 COL18A1
Gene Names
COL18A1
Chain
signal peptide:1-23, chain:24-1754, chain:1572-1754, chain:-1754
Reference Genes
BioGPS Gene:80781 COL18A1
COSMIC (genes):COL18A1 COL18A1
CTD Gene:80781 COL18A1
dbSNP Gene:80781 COL18A1
ENSEMBL:ENSG00000182871 COL18A1
HGNC:2195 COL18A1
KEGG:hsa:80781 COL18A1
Monarch:80781 COL18A1
NCBI Gene:80781 COL18A1
OMIM:120328 COL18A1
UCSC:P39060 COL18A1
Reference Transcript
RefSeq:NM_030582.3 COL18A1
RefSeq:NM_130445.3 COL18A1
RefSeq:NM_001379500.1 COL18A1
RefSeq:NM_130444.2 COL18A1
Participates
as a member of
Collagen alpha-1(XVIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
as a candidate of
Collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Collagen propeptides, chains [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-COL18A1(?-1754) [extracellular region]
GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
COL18A1(?-1754) [extracellular region]
COL18A1(1572-11754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
GalHyl-COL18A1(24-1754) [extracellular region]
5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-COL18A1(24-1754) [extracellular region]
GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-?) [extracellular region]
5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-?) [extracellular region]
GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-COL18A1(24-?) [extracellular region]
COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-?) [extracellular region]
COL18A1(?-1571) [extracellular region]
5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
Inferred To
Col18a1 [endoplasmic reticulum lumen]
(Mus musculus)
Col18a1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
let-2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Mp [endoplasmic reticulum lumen]
(Drosophila melanogaster)
col-115 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
emid1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Homologues of COL18A1(24-1754) [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
col-99 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
COL18A1 [endoplasmic reticulum lumen]
(Bos taurus)
COL18A1 [endoplasmic reticulum lumen]
(Canis familiaris)
COL18A1 [endoplasmic reticulum lumen]
(Gallus gallus)
COL18A1 [endoplasmic reticulum lumen]
(Sus scrofa)
Cross References
RefSeq
NP_001366429.1
,
NP_569712.2
,
NP_085059.2
,
NP_569711.2
OpenTargets
ENSG00000182871
ENSEMBL
ENSP00000347665
,
ENST00000355480
,
ENSP00000352798
,
ENST00000651438
,
ENSG00000182871
,
ENST00000359759
,
ENSP00000498485
GeneCards
COL18A1
HPA
ENSG00000182871-COL18A1
PRO
P39060
Pharos - Targets
P39060
GlyGen
P39060
Orphanet
COL18A1
HMDB Protein
HMDBP13479
PDB
1BNL
,
3HON
,
3HSH
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:28304 HEPARIN
0.564
2
UniProt:P08253 MMP2
5
MMP2(110-660) [extracellular region]
(R-HSA-381456)
MMP2(30-660) [extracellular region]
(R-HSA-1604364)
MMP2(67-660) [extracellular region]
(R-HSA-1604345)
MMP2(30-66) [extracellular region]
(R-HSA-1604347)
MMP2(67-109) [extracellular region]
(R-HSA-1604371)
0.527
2
UniProt:O60568 PLOD3
1
PLOD3 [endoplasmic reticulum membrane]
(R-HSA-1981135)
0.527
4
UniProt:O15460 P4HA2
1
P4HA2 [endoplasmic reticulum lumen]
(R-HSA-2980974)
0.527
3
UniProt:Q6ISS4 LAIR2
1
LAIR2 [extracellular region]
(R-HSA-5696342)
0.527
3
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