Reactome | 3x4Hyp-COL18A1(24-?) [extracellular region]

3x4Hyp-COL18A1(24-?) [extracellular region]

Stable Identifier

R-HSA-2470926

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

4-hydroxyprolyl collagen alpha-1(XVIII) chain N-term fragment

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Degradation of the extracellular matrix (Homo sapiens)
  - Collagen degradation (Homo sapiens)
    - Collagen type XVIII endostatin release (Homo sapiens)
      - Cleaved collagen type XVIII multimer [extracellular region] (Homo sapiens)
        
        Cleaved collagen type XVIII alpha chain trimer [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(XVIII) chain N-terminal fragments [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL18A1(24-?) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P39060 COL18A1

Gene Names

COL18A1

Chain

signal peptide:1-23, chain:24-1754, chain:1572-1754, chain:-1754

Reference Genes

BioGPS Gene:80781 COL18A1

COSMIC (genes):COL18A1 COL18A1

CTD Gene:80781 COL18A1

dbSNP Gene:80781 COL18A1

ENSEMBL:ENSG00000182871 COL18A1

HGNC:2195 COL18A1

KEGG:hsa:80781 COL18A1

Monarch:80781 COL18A1

NCBI Gene:80781 COL18A1

OMIM:120328 COL18A1

UCSC:P39060 COL18A1

Reference Transcript

Participates

as a member of

Collagen alpha-1(XVIII) chain N-terminal fragments [extracellular region] (Homo sapiens)

Other forms of this molecule

GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]

5Hyl-COL18A1(?-1754) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL18A1(?-1754) [extracellular region]

3x4Hyp-5Hyl-COL18A1(?-1754) [extracellular region]

3x4Hyp-GalHyl-COL18A1(?-1754) [extracellular region]

GalHyl-COL18A1(?-1754) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]

3x4Hyp-3Hyp-COL18A1(?-1754) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL18A1(?-1754) [extracellular region]

3x4Hyp-COL18A1(?-1754) [extracellular region]

GlcGalHyl-COL18A1(?-1754) [extracellular region]

3x4Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]

COL18A1(?-1754) [extracellular region]

COL18A1(1572-11754) [extracellular region]

3x4Hyp-5Hyl-COL18A1(24-1754) [extracellular region]

3x4Hyp-GalHyl-COL18A1(24-1754) [extracellular region]

COL18A1(24-1754) [extracellular region]

3x4Hyp-3Hyp-COL18A1(24-1754) [extracellular region]

3x4Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]

GalHyl-COL18A1(24-1754) [extracellular region]

5Hyl-COL18A1(24-1754) [extracellular region]

3x4Hyp-COL18A1(24-1754) [extracellular region]

GlcGalHyl-COL18A1(24-1754) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [extracellular region]

3x4Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]

3x4Hyp-GalHyl-COL18A1(24-?) [extracellular region]

5Hyl-COL18A1(24-?) [extracellular region]

3x4Hyp-5Hyl-COL18A1(24-?) [extracellular region]

3x4Hyp-3Hyp-COL18A1(24-?) [extracellular region]

GlcGalHyl-COL18A1(24-?) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]

GalHyl-COL18A1(24-?) [extracellular region]

COL18A1(24-?) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL18A1(24-?) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL18A1(24-?) [extracellular region]

COL18A1(?-1571) [extracellular region]

5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]

Inferred To

Col18a1 [extracellular region] (Mus musculus)

Col18a1 [extracellular region] (Rattus norvegicus)

Homologues of 3x4Hyp-COL18A1(24-?) [extracellular region] (Caenorhabditis elegans)

col-99 [extracellular region] (Caenorhabditis elegans)

Mp [extracellular region] (Drosophila melanogaster)

COL18A1 [extracellular region] (Bos taurus)

COL18A1 [extracellular region] (Canis familiaris)

COL18A1 [extracellular region] (Gallus gallus)

COL18A1 [extracellular region] (Sus scrofa)

col-115 [extracellular region] (Caenorhabditis elegans)

emid1 [extracellular region] (Xenopus tropicalis)

let-2 [extracellular region] (Caenorhabditis elegans)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Cross References

RefSeq

NP_001366429.1, NP_569712.2, NP_085059.2, NP_569711.2

OpenTargets

ENSG00000182871

ENSEMBL

ENSP00000347665, ENST00000355480, ENSP00000352798, ENST00000651438, ENSG00000182871, ENST00000359759, ENSP00000498485

GeneCards

COL18A1

HPA

ENSG00000182871-COL18A1

PRO

P39060

Pharos - Targets

P39060

GlyGen

P39060

Orphanet

COL18A1

HMDB Protein

HMDBP13479

PDB

1BNL, 3HON, 3HSH

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
ChEBI:28304 HEPARIN			0.564	2
UniProt:P08253 MMP2	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(67-109) [extracellular region] (R-HSA-1604371)	0.527	2
UniProt:O60568 PLOD3	1	PLOD3 [endoplasmic reticulum membrane] (R-HSA-1981135)	0.527	4
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.527	3
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.527	3

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