HOXC4 chromatin is activated

Stable Identifier
Reaction [omitted]
Homo sapiens
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As inferred from mouse embryos, HOXC4 is expressed at E12.5 caudal to rhombomere 7 (r7) and at the level of prevertebrae 4-5 and caudally. In carcinoma cells treated with retinoic acid (Lee et al. 2007) and primary fibroblasts (Lan et al. 2007) chromatin at HOXC4 loses methylation at lysine-27 of histone H3 (H3K27me3), loses polycomb repressive complex 2 (PRC2), and gains methylation at lysine-4 of histone H3 (H3K4me3). In embryonal carcinoma cells KDM6A (UTX) binds HOXC4 and participates in demethylating H3K27 at HOXC4 (Lee et al. 2007)

Literature References
PubMed ID Title Journal Year
17851529 A histone H3 lysine 27 demethylase regulates animal posterior development

Canaani, E, Roberts, TM, Bayliss, PE, Chen, S, Iwase, S, Alpatov, R, Whetstine, JR, Chang, HY, Issaeva, I, Shi, Y, Lan, F, Wang, JK, Rinn, JL

Nature 2007
17761849 Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

Di Croce, L, Trojer, P, Reinberg, D, Lee, MG, Villa, R, Yan, KP, Shiekhattar, R, Norman, J

Science 2007
Catalyst Activity

histone H3-tri/di-methyl-lysine-27 demethylase activity of MLL2,3 complex [nucleoplasm]

Inferred From
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