Activation of Latent HCMV Genome

Stable Identifier
R-HSA-9614810
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
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A cell containing a repressed or latent Human Cytomegalovirus (HCMV) genome sits quietly carrying on its normal cellular functions. The HCMV silenced HCMV geneome can be activated by a number of celluar events or state changes. Reactivation of HCMV lytic infection is correlated to changes in histone modifications around the MIEP promoter resulting in a new chromatin structure conducive to transcriptional activity. These changes are intimately linked with cell differentiation, a phenomenon known to reactivate latent virus in vivo.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
19682613 Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection

Sinclair, J

Biochim. Biophys. Acta 2010
Participants
Participant Of
Disease
Name Identifier Synonyms
viral infectious disease 934 arbovirus infectious disease, Viral disease, Viral infection NOS, Viral infection, unspecified (disorder), Viral infection NOS, Viral disease (disorder), Viral disease, Viral infection NOS (disorder), Viral Infection, virus infection, virus infection, Viral: [infection NOS] or [illness]
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