p-6Y-FGFR2b C3 variant [plasma membrane]

Stable Identifier
R-HSA-2029870
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phosphorylated FGFR2b C3 variant, p-6Y-FGFR2-17, Ksam-IIC3
Icon
p-6Y-FGFR2b C3 variant [plasma membrane] icon
p-6Y-FGFR2b C3 variant [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
19103595 Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform

Cha, JY, Maddileti, S, Mitin, N, Harden, TK, Der, CJ

J Biol Chem 2009
8205545 Preferential alternative splicing in cancer generates a K-sam messenger RNA with higher transforming activity

Itoh, H, Hattori, Y, Sakamoto, H, Ishii, H, Kishi, T, Sasaki, H, Yoshida, T, Koono, M, Sugimura, T, Terada, M

Cancer Res 1994
External Reference Information
External Reference
UniProt:P21802-17 FGFR2
Gene Names
FGFR2, BEK, KGFR, KSAM
Other Identifiers
1143_s_at
1144_at
1145_g_at
11739249_a_at
11740159_x_at
11740394_a_at
11740395_a_at
11740409_a_at
11751508_a_at
11752116_a_at
11753370_s_at
11762105_at
11762745_x_at
11762987_x_at
1363_at
16719025
1970_s_at
203638_PM_s_at
203638_s_at
203639_PM_s_at
203639_s_at
208225_PM_at
208225_at
208228_PM_s_at
208228_s_at
208234_PM_x_at
208234_x_at
211401_PM_s_at
211401_s_at
2263
240913_PM_at
240913_at
3310108
3310109
3310110
3310111
3310112
3310113
3310114
3310115
3310117
3310118
3310119
3310120
3310121
3310122
3310123
3310125
3310126
3310128
3310129
3310132
3310133
3310137
3310138
3310139
3310141
3310142
3310143
3310144
3310146
3310147
3310148
3310149
3310150
3310154
3310155
3310156
3310157
3310158
3310159
3310161
3310162
3310164
3310165
3310166
3310168
3310173
3310174
3310175
3310176
3310178
3310179
3310195
3310203
3310204
3310205
3310206
3310207
3310208
3310209
3310210
3310211
3310368
3310370
3310378
3310383
3310385
34354_at
73572_at
7936734
84435_at
A_23_P303145
A_23_P303149
A_24_P206624
GE61433
GE798271
GO:0000122
GO:0000166
GO:0001525
GO:0001657
GO:0001701
GO:0001837
GO:0002053
GO:0003148
GO:0003149
GO:0003416
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005794
GO:0005886
GO:0005938
GO:0006355
GO:0006468
GO:0006915
GO:0007267
GO:0007409
GO:0008201
GO:0008284
GO:0008543
GO:0008589
GO:0009791
GO:0009880
GO:0009887
GO:0009986
GO:0010518
GO:0010647
GO:0010839
GO:0016020
GO:0016301
GO:0016331
GO:0016740
GO:0017134
GO:0018108
GO:0021769
GO:0021847
GO:0021860
GO:0022612
GO:0023056
GO:0030154
GO:0030177
GO:0030282
GO:0030324
GO:0030855
GO:0030901
GO:0030916
GO:0031069
GO:0031410
GO:0032496
GO:0032808
GO:0033688
GO:0035265
GO:0035602
GO:0035603
GO:0035604
GO:0035607
GO:0042472
GO:0042476
GO:0042802
GO:0042803
GO:0043009
GO:0043235
GO:0043410
GO:0044344
GO:0045165
GO:0045471
GO:0045595
GO:0045667
GO:0045787
GO:0045944
GO:0046777
GO:0048286
GO:0048333
GO:0048557
GO:0048562
GO:0048565
GO:0048568
GO:0048608
GO:0048701
GO:0048705
GO:0048730
GO:0048755
GO:0048762
GO:0048856
GO:0050679
GO:0050680
GO:0051150
GO:0051781
GO:0055010
GO:0060045
GO:0060076
GO:0060174
GO:0060348
GO:0060349
GO:0060442
GO:0060445
GO:0060449
GO:0060463
GO:0060484
GO:0060501
GO:0060512
GO:0060523
GO:0060527
GO:0060529
GO:0060595
GO:0060601
GO:0060615
GO:0060664
GO:0060667
GO:0060670
GO:0060688
GO:0060915
GO:0060916
GO:0070372
GO:0070374
GO:0071300
GO:0071456
GO:0071560
GO:0090263
GO:0140096
GO:1904707
GO:1904888
HMNXSV003001516
HMNXSV003003698
HMNXSV003045562
HMNXSV003050281
ILMN_1682270
M87770_at
PH_hs_0024624
TC10001711.hg
g13186252_3p_a_at
g13186256_3p_at
g13186266_3p_a_at
g186740_3p_a_at
g186781_3p_a_at
g6691454_3p_a_at
g6691454_3p_x_at
Participates
as a component of
Other forms of this molecule
FGFR2b C3 variant [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 467
Coordinate
467
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 587
Coordinate
587
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 589
Coordinate
589
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 657
Coordinate
657
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 658
Coordinate
658
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 734
Coordinate
734
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
IntEnz
HPA
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (31)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P09038 FGF2  1 0.779 5
 UniProt:P51812 RPS6KA3  7 0.745 5
 UniProt:P62993 GRB2  1 0.735 6
 ChEBI:73280 SSR      0.683 8
 UniProt:P05230 FGF1  1 0.675 3
 UniProt:P11362 FGFR1  9 0.623 3
 UniProt:O15520 FGF10  1 0.571 2
 UniProt:P06734 FCER2  1 0.558 2
 UniProt:P19174 PLCG1  6 0.528 3
 UniProt:Q3MIR4 CC50B      0.527 2
 UniProt:O60637 TSN3      0.527 2
 UniProt:Q96LL9 DJC30      0.527 2
 UniProt:Q6P047 CH074      0.527 2
 UniProt:Q99732 LITAF      0.527 2
 UniProt:Q8N7X8 SIGL1      0.527 2
 UniProt:Q5T9A4 ATAD3B  3 0.527 2
 UniProt:Q96HB5 CC120      0.527 2
 UniProt:Q8IWX8 CHERP  1 0.527 2
 UniProt:Q92551 IP6K1  2 0.527 2
 UniProt:Q6P995 F171B      0.527 2
 UniProt:Q92575 UBXN4      0.527 2
 UniProt:Q96L94 SNX22      0.527 2
 UniProt:Q96G30 MRAP2      0.527 2
 UniProt:P55899 FCGRN      0.527 2
 UniProt:Q5TF58 IFFO2      0.527 2
 UniProt:P34741 SDC2  20 0.527 2
 UniProt:P01033 TIMP1  4 0.527 2
 UniProt:Q06124 PTPN11  4 0.519 2
 UniProt:Q9ULH0 KIDINS220  2 0.483 2
 UniProt:Q9UBH6 S53A1      0.483 2
 UniProt:Q86VI4 LAP4B      0.463 2
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