Reactome | ACVR2A [plasma membrane]

ACVR2A [plasma membrane]

Stable Identifier

R-HSA-201659

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ACVR2, Activin receptor type II, AVR2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P27037 ACVR2A

Gene Names

ACVR2A, ACVR2

Chain

signal peptide:1-19, chain:20-513

Reference Genes

BioGPS Gene:92 ACVR2A

COSMIC (genes):ACVR2A ACVR2A

CTD Gene:92 ACVR2A

dbSNP Gene:92 ACVR2A

ENSEMBL:ENSG00000121989 ACVR2A

HGNC:173 ACVR2A

KEGG:hsa:92 ACVR2A

Monarch:92 ACVR2A

NCBI Gene:92 ACVR2A

OMIM:102581 ACVR2A

UCSC:P27037 ACVR2A

Reference Transcript

Other Identifiers

11727163_a_at

11727164_at

11752492_a_at

16886308

205327_PM_s_at

205327_s_at

228416_PM_at

228416_at

2509558

2509560

2509561

2509562

2509578

2509579

2509580

2509581

2509582

2509583

2509585

2509586

2509587

2509589

2509590

2509591

2509592

2509594

2509596

2509597

2509598

2509599

2509600

2509601

2509611

2509613

35162_s_at

53468_at

62358_at

8045587

A_14_P109940

A_14_P122941

A_14_P128551

A_23_P153930

GE486534

GE58150

GO:0001649

GO:0001702

GO:0001934

GO:0003824

GO:0004672

GO:0004674

GO:0004675

GO:0005025

GO:0005026

GO:0005515

GO:0005524

GO:0005737

GO:0005886

GO:0006355

GO:0006468

GO:0007178

GO:0007283

GO:0007368

GO:0007389

GO:0007498

GO:0008584

GO:0009952

GO:0009966

GO:0009986

GO:0015026

GO:0016020

GO:0016361

GO:0016362

GO:0016740

GO:0017002

GO:0019838

GO:0022414

GO:0030154

GO:0030165

GO:0030501

GO:0030509

GO:0032924

GO:0032927

GO:0034673

GO:0034711

GO:0042475

GO:0042713

GO:0042802

GO:0043084

GO:0043235

GO:0045428

GO:0045648

GO:0045669

GO:0045944

GO:0046872

GO:0048179

GO:0048185

GO:0048706

GO:0048856

GO:0051239

GO:0060011

GO:0060089

GO:0060391

GO:0070123

GO:0071363

GO:0071773

GO:0098821

GO:0140096

GO:0141091

HMNXSV003013244

HMNXSV003051576

Hs.33412.0.A1_3p_at

ILMN_1670912

ILMN_2152711

M93415_at

PH_hs_0018877

TC02000923.hg

g10862696_3p_a_at

Participates

as an input of

InhibinA-TGFBR3 binding to ACVR2A (Homo sapiens)

as a member of

as a component of

INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)

Inferred To

put [plasma membrane] (Drosophila melanogaster)

acvr2a [plasma membrane] (Xenopus tropicalis)

Acvr2a [plasma membrane] (Mus musculus)

Acvr2a [plasma membrane] (Rattus norvegicus)

ACVR2A [plasma membrane] (Bos taurus)

ACVR2A [plasma membrane] (Canis familiaris)

ACVR2A [plasma membrane] (Gallus gallus)

ACVR2A [plasma membrane] (Sus scrofa)

daf-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_047302248.1, XP_054200482.1, NP_001607.1, NP_001265509.1, NP_001265508.1

ZINC - World Drugs

AVR2A_HUMAN

Guide to Pharmacology - Targets

1791

OpenTargets

ENSG00000121989

ENSEMBL

ENSP00000241416, ENSG00000121989, ENSP00000384338, ENST00000404590, ENSP00000439988, ENST00000241416, ENST00000535787

ZINC - FDA approved

AVR2A_HUMAN

ZINC - Substances

AVR2A_HUMAN

ZINC - Biogenic

AVR2A_HUMAN

ZINC target

P27037

PRO

P27037

GlyGen

P27037

PDB

3SOC, 7U5P, 5NH3, 4ASX, 3Q4T

ZINC - Investigational

AVR2A_HUMAN

IntEnz

2.7.11.30

HPA

ENSG00000121989-ACVR2A

GeneCards

ACVR2A

Pharos - Targets

P27037

ZINC - Predictions - Purchasable

AVR2A_HUMAN

HMDB Protein

HMDBP01519

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.527	2
UniProt:Q9Y3C5 RNF11			0.527	2
UniProt:Q13705 ACVR2B	1	ACVR2B [plasma membrane] (R-HSA-201656)	0.527	4
UniProt:Q96G30 MRAP2			0.527	2
UniProt:Q9WVQ1 MAGI2			0.508	2

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