Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
acvr2a [plasma membrane]
Stable Identifier
R-XTR-201659
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
plasma membrane
Synonyms
ACVR2A, F6R871
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
Signaling by TGFB family members (Xenopus tropicalis)
Signaling by Activin (Xenopus tropicalis)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)
Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane] (Xenopus tropicalis)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane] (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Signaling by BMP (Xenopus tropicalis)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMP2 binds to the receptor complex (Xenopus tropicalis)
BMP:BMPRII:BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII:BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMPRII:BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Formation of a heteromeric BMP receptor complex (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMPRII:BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
I-Smad competes with R-Smad1/5/8 for type I receptor (Xenopus tropicalis)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Xenopus tropicalis)
BMP:p-BMPR:Endofin [early endosome membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Type II receptor phosphorylates type I receptor (Xenopus tropicalis)
BMP:BMPRII:BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII:BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Xenopus tropicalis)
BMPRII dimer [plasma membrane] (Xenopus tropicalis)
Type II receptor [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
Signaling by TGFBR3 (Xenopus tropicalis)
TGFBR3 regulates activin signaling (Xenopus tropicalis)
InhibinA-TGFBR3 binding to ACVR2A (Xenopus tropicalis)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
acvr2a [plasma membrane] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:F6R871
Gene Names
acvr2a
Reference Genes
BioGPS Gene:100216172 acvr2a
ENSEMBL:ENSXETG00000021720
Monarch:100216172 acvr2a
NCBI Gene:100216172 acvr2a
UCSC:F6R871 acvr2a
Reference Transcript
RefSeq:XM_018097055.2 acvr2a
Other Identifiers
100216172
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005524
GO:0005886
GO:0007154
GO:0007178
GO:0007389
GO:0016020
GO:0016301
GO:0016740
GO:0017002
GO:0023052
GO:0032502
GO:0032924
GO:0046872
GO:0048179
GO:0048185
GO:0071363
GO:0140096
Participates
as an input of
InhibinA-TGFBR3 binding to ACVR2A (Xenopus tropicalis)
as a member of
Type II receptor [plasma membrane] (Xenopus tropicalis)
ACVR2A,B [plasma membrane] (Xenopus tropicalis)
as a component of
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Xenopus tropicalis)
Inferred From
ACVR2A [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_017952544.1
ENSEMBL
ENSXETP00000046976
,
ENSXETG00000021720
,
ENSXETT00000046976
Xenbase
XB-GENE-484012
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text