Reactome | ACVR2B [plasma membrane]

ACVR2B [plasma membrane]

Stable Identifier

R-HSA-201656

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Activin receptor type IIB, AVRB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13705 ACVR2B

Gene Names

ACVR2B

Chain

signal peptide:1-18, chain:19-512

Reference Genes

BioGPS Gene:93 ACVR2B

COSMIC (genes):ACVR2B ACVR2B

CTD Gene:93 ACVR2B

dbSNP Gene:93 ACVR2B

ENSEMBL:ENSG00000114739 ACVR2B

HGNC:174 ACVR2B

KEGG:hsa:93 ACVR2B

Monarch:93 ACVR2B

NCBI Gene:93 ACVR2B

OMIM:602730 ACVR2B

UCSC:Q13705 ACVR2B

Reference Transcript

RefSeq:NM_001106.3 ACVR2B

Other Identifiers

11727681_a_at

11727682_at

1559548_PM_at

1559548_at

16939231

16939247

220028_PM_at

220028_at

236126_PM_at

236126_at

2617747

2617749

2617751

2617753

2617754

2617763

2617764

2617765

2617766

2617767

2617768

2617769

2617770

2617772

2617774

2617775

2617777

2617778

2617780

2617782

2617784

2617785

2617787

2617789

2617790

2617792

2617794

2617795

2617797

2617798

2617799

2617800

2617801

2617802

2617803

2617804

2617805

2617806

2617807

39314_at

46395_at

8078805

83180_at

A_23_P109950

A_24_P231132

A_32_P134209

GE498204

GE60029

GE62354

GE857162

GO:0000122

GO:0001501

GO:0001702

GO:0001822

GO:0001946

GO:0001974

GO:0003824

GO:0004672

GO:0004674

GO:0004675

GO:0004712

GO:0005515

GO:0005524

GO:0005737

GO:0005886

GO:0006355

GO:0006468

GO:0007165

GO:0007178

GO:0007368

GO:0007389

GO:0007498

GO:0007507

GO:0009749

GO:0009791

GO:0009952

GO:0009966

GO:0016020

GO:0016362

GO:0016740

GO:0017002

GO:0019209

GO:0019222

GO:0019838

GO:0030073

GO:0030154

GO:0030324

GO:0030501

GO:0030509

GO:0031016

GO:0032924

GO:0032927

GO:0032991

GO:0035265

GO:0042475

GO:0043235

GO:0045669

GO:0046872

GO:0048179

GO:0048185

GO:0048617

GO:0048705

GO:0048856

GO:0051239

GO:0060021

GO:0060089

GO:0060836

GO:0060840

GO:0060841

GO:0061298

GO:0071363

GO:0098772

GO:0120163

GO:0140096

GO:0141091

HMNXSV003016816

HMNXSV003053705

Hs.42302.0.A1_3p_at

Hs2.174273.1.S1_3p_at

ILMN_1668983

ILMN_1824337

PH_hs_0002117

TC03000192.hg

X77533_at

g10862697_3p_at

Participates

as a member of

as a component of

Inferred To

put [plasma membrane] (Drosophila melanogaster)

ACVR2B [plasma membrane] (Bos taurus)

ACVR2B [plasma membrane] (Caenorhabditis elegans)

ACVR2B [plasma membrane] (Canis familiaris)

ACVR2B [plasma membrane] (Gallus gallus)

ACVR2B [plasma membrane] (Mus musculus)

ACVR2B [plasma membrane] (Rattus norvegicus)

ACVR2B [plasma membrane] (Sus scrofa)

acvr2ba [plasma membrane] (Danio rerio)

acvr2b [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001097.2

Guide to Pharmacology - Targets

1792

ENSEMBL

ENST00000352511, ENSP00000340361, ENSG00000114739

OpenTargets

ENSG00000114739

ZINC - FDA approved

AVR2B_HUMAN

ZINC - Substances

AVR2B_HUMAN

ZINC - Biogenic

AVR2B_HUMAN

ZINC target

Q13705

PRO

Q13705

GlyGen

Q13705

PDB

5NGV, 5NHR, 7OLY, 7MRZ, 2QLU, 2H62, 4FAO

ZINC - Investigational

AVR2B_HUMAN

GeneCards

ACVR2B

HPA

ENSG00000114739-ACVR2B

Pharos - Targets

Q13705

Orphanet

ACVR2B

ZINC - Predictions - Purchasable

AVR2B_HUMAN

HMDB Protein

HMDBP01150

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.527	3
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:P80370 DLK1	1	DLK1 [plasma membrane] (R-HSA-1604447)	0.527	2

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