Reactome | InhibinA-TGFBR3 binding to ACVR2A

InhibinA-TGFBR3 binding to ACVR2A

Stable Identifier

R-HSA-9839405

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

3/5

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TGFBR3 (Betaglycan) binds inhibinA with high affinity and enhances binding in cells co-expressing ACVR2A (Activin Receptor II) and TGBFR3. ACVR2A (Activin Receptor II) is also co-receptor for Activin signalling. Inhibin-TGFBR3 binding to ACVR2A results in a competitive antagonism of Activin signaling (Lewis et al., 2000). Also, TGFBR3 inhibits BMP signaling by 2 mechanisms: 1. Inhibin competes with BMP7 for type II activin receptors, and this competition is facilitated by TGFBR3 (betaglycan), 2. TGFBR3 also enables inhibin to bind to and compete with BMP2 for binding to the BMP-specific type II receptor BMPRII, which does not bind inhibin in the absence of TGFBR3 (Wiater et al, 2003)

Literature References

PubMed ID	Title	Journal	Year
12493742	Inhibin is an antagonist of bone morphogenetic protein signaling Wiater, E, Vale, W	J Biol Chem	2003
10746731	Betaglycan binds inhibin and can mediate functional antagonism of activin signalling Bilezikjian, LM, MacConell, LA, Vale, W, Gray, PC, Wiater, E, Lewis, KA, Blount, AL	Nature	2000