Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BMP2 dimer [extracellular region]
Stable Identifier
R-HSA-201463
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 binds BAX gene promoter (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 binds to the receptor complex (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
Ligand Trap:BMP2 [extracellular region] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
Type II receptor phosphorylates type I receptor (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
Participants
components
x 2
BMP2 [extracellular region]
(Homo sapiens)
Participates
as a component of
Ligand Trap:BMP2 [extracellular region] (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
as an input of
The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)
BMP2 binds to the receptor complex (Homo sapiens)
This entity regulates
Positively
RUNX2 binds BAX gene promoter
(Homo sapiens)
DLX5,(DLX6) binds RUNX2 gene promoter
(Homo sapiens)
Inferred To
BMP2 dimer [extracellular region]
(Bos taurus)
BMP2 dimer [extracellular region]
(Caenorhabditis elegans)
BMP2 dimer [extracellular region]
(Canis familiaris)
BMP2 dimer [extracellular region]
(Danio rerio)
BMP2 dimer [extracellular region]
(Drosophila melanogaster)
BMP2 dimer [extracellular region]
(Gallus gallus)
BMP2 dimer [extracellular region]
(Mus musculus)
BMP2 dimer [extracellular region]
(Rattus norvegicus)
BMP2 dimer [extracellular region]
(Sus scrofa)
BMP2 dimer [extracellular region]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text