The ligand trap binds the ligand BMP2, blocking BMP signalling

Stable Identifier
R-HSA-201810
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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The ligand trap binds the ligand BMP2, blocking BMP signalling
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BMP ligand traps are cystine-knot containing proteins which bind BMPs and antagonise their actions. They are active during organ development and morphogenesis. Different BMP ligand traps show specific spatio-temporal expression during development, and selective activity against specific BMP ligands.
Literature References
PubMed ID Title Journal Year
17029022 Bone morphogenetic proteins and their antagonists

Gazzerro, E, Canalis, E

Rev Endocr Metab Disord 2006
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
sequestering of BMP from receptor via BMP binding (0038098)
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The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Sus scrofa)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Xenopus tropicalis)
Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)
Created
Jassal, B  (2007-09-25)
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