RUNX2 binds BAX gene promoter

Stable Identifier
R-HSA-9008832
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2 binds BAX gene promoter
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RUNX2, presumably in complex with CBFB, binds the promoter of the BAX gene (Eliseev et al. 2008, Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012). Signaling downstream of BMP2 promotes RUNX2-mediated activation of the BAX gene transcription (Eliseev et al. 2008). Dephosphorylation of RUNX2 serine residue S432 by the PPM1D (WIP1) serine/threonine phosphatase promotes association of RUNX2 with the BAX promoter (Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).

Literature References
PubMed ID Title Journal Year
18223689 Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis

Rosier, RN, Zuscik, MJ, Drissi, MH, Dong, YF, Schwarz, EM, Sampson, E, Eliseev, RA, O'Keefe, RJ

Oncogene 2008
22065775 Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Hammann, A, Garrido, C, Goloudina, AR, Bulavin, DV, Appella, E, Tanoue, K, le Guezennec, X, Demidov, ON, Fourmaux, E, Mazur, SJ

Proc. Natl. Acad. Sci. U.S.A. 2012
22544321 Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

Garrido, C, Goloudina, AR, Appella, E, Demidov, ON, Mazur, SJ

Cell Cycle 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
BMP2 dimer [extracellular region] (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-13)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-13)
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