BMP2 binds to the receptor complex

Stable Identifier
R-HSA-201457
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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BMP2 binds to the receptor complex
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The mature dimeric BMP2 binds with high affinity to its signalling receptor, the type II receptor serine/threonine kinase. The type II receptor is known to form dimeric complexes even in the absence of BMP2 (Rosenzweig et al.1995).

Literature References
PubMed ID Title Journal Year
7644468 Cloning and characterization of a human type II receptor for bone morphogenetic proteins

Rosenzweig, BL, Imamura, T, Okadome, T, Cox, GN, Yamashita, H, ten Dijke, P, Heldin, CH, Miyazono, K

Proc Natl Acad Sci U S A 1995
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transforming growth factor beta receptor binding activity of BMP2 dimer [extracellular region]
Physical Entity
BMP2 dimer [extracellular region]
Activity
transforming growth factor beta receptor binding (0005160)
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Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)
Created
Jassal, B  (2007-08-13)