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BMP2 [extracellular region]
Stable Identifier
R-HSA-201456
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Bone morphogenetic protein 2, BMP2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 binds BAX gene promoter (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP2 binds to the receptor complex (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
Ligand Trap:BMP2 [extracellular region] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
Type II receptor phosphorylates type I receptor (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP2 dimer [extracellular region] (Homo sapiens)
BMP2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12643 BMP2
Gene Names
BMP2, BMP2A
Chain
signal peptide:1-23, propeptide:24-282, chain:283-396
Reference Genes
BioGPS Gene:650 BMP2
COSMIC (genes):BMP2 BMP2
CTD Gene:650 BMP2
dbSNP Gene:650 BMP2
ENSEMBL:ENSG00000125845 BMP2
HGNC:1069 BMP2
KEGG:hsa:650 BMP2
Monarch:650 BMP2
NCBI Gene:650 BMP2
OMIM:112261 BMP2
UCSC:P12643 BMP2
Reference Transcript
RefSeq:NM_001200.3 BMP2
Other Identifiers
1113_at
11743497_at
11743498_at
16911261
205289_PM_at
205289_at
205290_PM_s_at
205290_s_at
3875422
3875424
3875425
3875426
3875427
3875428
3875430
3875431
3875432
3875435
3875436
3875437
40367_at
59306_at
650
8060850
A_23_P143331
A_33_P3237150
A_33_P3346543
GE57870
GO:0000122
GO:0001501
GO:0001503
GO:0001649
GO:0001658
GO:0001666
GO:0001701
GO:0001837
GO:0001934
GO:0002062
GO:0003129
GO:0003133
GO:0003176
GO:0003181
GO:0003203
GO:0003210
GO:0003272
GO:0003331
GO:0005102
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006029
GO:0006351
GO:0006355
GO:0006366
GO:0006954
GO:0007219
GO:0007267
GO:0007507
GO:0008083
GO:0008284
GO:0008285
GO:0009617
GO:0009887
GO:0009986
GO:0010467
GO:0010628
GO:0010629
GO:0010718
GO:0010894
GO:0010922
GO:0019211
GO:0021537
GO:0021978
GO:0023052
GO:0030154
GO:0030177
GO:0030282
GO:0030316
GO:0030335
GO:0030501
GO:0030509
GO:0030512
GO:0030858
GO:0031648
GO:0032092
GO:0032348
GO:0033690
GO:0035051
GO:0035054
GO:0035360
GO:0036305
GO:0039706
GO:0042475
GO:0042482
GO:0042487
GO:0043065
GO:0043226
GO:0043231
GO:0043407
GO:0043410
GO:0043539
GO:0043569
GO:0045165
GO:0045599
GO:0045600
GO:0045666
GO:0045669
GO:0045778
GO:0045786
GO:0045892
GO:0045893
GO:0045944
GO:0048018
GO:0048662
GO:0048708
GO:0048711
GO:0048762
GO:0048839
GO:0048856
GO:0051042
GO:0051091
GO:0051148
GO:0051216
GO:0055007
GO:0055008
GO:0060039
GO:0060128
GO:0060129
GO:0060317
GO:0060348
GO:0060391
GO:0060426
GO:0060485
GO:0061036
GO:0070374
GO:0070700
GO:0070724
GO:0071363
GO:0071407
GO:0071773
GO:0072138
GO:0090090
GO:0098772
GO:1900159
GO:1900745
GO:1901135
GO:1901331
GO:1902895
GO:1905072
GO:1905222
GO:2000065
GO:2000726
HMNXSV003016369
HMNXSV003055468
Hs.73853.0.S2_3p_at
ILMN_1722718
M22489_at
PH_hs_0004220
TC20000067.hg
g4557368_3p_a_at
Participates
as a component of
BMP2 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
BMP2(24-396) [extracellular region]
Inferred To
Homologues of BMP2 [extracellular region]
(Caenorhabditis elegans)
Homologues of BMP2 [extracellular region]
(Drosophila melanogaster)
mav [extracellular region]
(Drosophila melanogaster)
dbl-1 [extracellular region]
(Caenorhabditis elegans)
BMP2 [extracellular region]
(Bos taurus)
BMP2 [extracellular region]
(Canis familiaris)
BMP2 [extracellular region]
(Gallus gallus)
BMP2 [extracellular region]
(Sus scrofa)
daf-7 [extracellular region]
(Caenorhabditis elegans)
bmp2 [extracellular region]
(Xenopus tropicalis)
Bmp2 [extracellular region]
(Mus musculus)
Bmp2 [extracellular region]
(Rattus norvegicus)
bmp2b [extracellular region]
(Danio rerio)
dpp [extracellular region]
(Drosophila melanogaster)
unc-129 [extracellular region]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000125845
ENSEMBL
ENSP00000368104
,
ENSG00000125845
,
ENST00000378827
HPA
ENSG00000125845-BMP2
GeneCards
BMP2
ZINC - Substances
BMP2_HUMAN
ZINC target
P12643
PRO
P12643
Pharos - Targets
P12643
Orphanet
BMP2
GlyGen
P12643
PDB
4UI1
,
1REW
,
4UI0
,
1REU
,
8E3G
,
2GOO
,
2H62
,
3BK3
,
1ES7
,
2H64
,
4N1D
,
6OMN
,
2QJB
,
4UI2
,
2QJA
,
4UHY
,
3BMP
,
2QJ9
,
4MID
,
4UHZ
,
7AG0
HMDB Protein
HMDBP02308
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P97798 Neo1
1
Neogenin [plasma membrane]
(R-MMU-421657)
0.602
3
UniProt:P27038 Acvr2a
1
Acvr2a [plasma membrane]
(R-MMU-1225869)
0.544
2
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