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BMP2 dimer [extracellular region]
Stable Identifier
R-RNO-201463
Type
Complex
Species
Rattus norvegicus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by BMP (Rattus norvegicus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP2 binds to the receptor complex (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP:BMPRII:BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
I-Smad competes with R-Smad1/5/8 for type I receptor (Rattus norvegicus)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Rattus norvegicus)
BMP:p-BMPR:Endofin [early endosome membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
Ligand Trap:BMP2 [extracellular region] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
Type II receptor phosphorylates type I receptor (Rattus norvegicus)
BMP:BMPRII:BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP2 dimer [extracellular region] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Bmp2 [extracellular region]
(Rattus norvegicus)
Participates
as an input of
The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)
BMP2 binds to the receptor complex (Rattus norvegicus)
as a component of
Ligand Trap:BMP2 [extracellular region] (Rattus norvegicus)
BMP:BMPRII:BMPRI [plasma membrane] (Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Rattus norvegicus)
BMP:p-BMPR:Endofin [early endosome membrane] (Rattus norvegicus)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Rattus norvegicus)
Inferred From
BMP2 dimer [extracellular region]
(Homo sapiens)
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