Formation of a Nef:ARF1:CD4 complex

Stable Identifier
R-HSA-200879
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol, early endosome membrane, plasma membrane
ReviewStatus
5/5
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Formation of a Nef:ARF1:CD4 complex
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The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting. The small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4. Nef binds ARF1 directly and can recruit the GTPase onto endosomal membranes, leading to the eventual degradation of CD4 (Faure et al. 2004).
Literature References
PubMed ID Title Journal Year
15202998 ARF1 regulates Nef-induced CD4 degradation

Faure, J, Stalder, R, Borel, C, Sobo, K, Piguet, V, Demaurex, N, Gruenberg, J, Trono, D

Curr Biol 2004
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Input
Output
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as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Gillespie, ME  (2007-07-25)
Reviewed
Skowronski, J  (2007-08-07)
Created
Gillespie, ME  (2007-07-25)
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