mTORC1 phosphorylates AKT1S1

Stable Identifier
R-HSA-5672828
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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AKT1S1 (PRAS40) is phosphorylated by AKT at Thr246, which leads to the binding of YWHAB (14-3-3 beta) (Zhang et al. 2002, Kovacina et al. 2003. AKT1S1 is phosphorylated at Ser183 by mTORC1 (Oshiro et al. 2007); mutation of Ser183 decreases the affinity of AKT1S1 with YWHAB. As AKT1S1 suppresses mTORC1 phosphorylation of S6K1 and 4E-BP1 (Oshiro et al. 2007), binding of YWHAB is proposed to relieve this inhibition (Wang et al. 2012).
Literature References
PubMed ID Title Journal Year
17517883 The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

Takehana, K, Yonezawa, K, Tanimura, K, Oshiro, N, Miyamoto, T, Takahashi, R, Avruch, J, Nakashima, A, Hara, K, Yoshino, K, Kikkawa, U, Eguchi, S

J Biol Chem 2007
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane]

Orthologous Events
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