AKT1S1 (PRAS40) is phosphorylated by AKT at Thr246, which leads to the binding of YWHAB (14-3-3 beta) (Zhang et al. 2002, Kovacina et al. 2003. AKT1S1 is phosphorylated at Ser183 by mTORC1 (Oshiro et al. 2007); mutation of Ser183 decreases the affinity of AKT1S1 with YWHAB. As AKT1S1 suppresses mTORC1 phosphorylation of S6K1 and 4E-BP1 (Oshiro et al. 2007), binding of YWHAB is proposed to relieve this inhibition (Wang et al. 2012).
Takehana, K, Yonezawa, K, Tanimura, K, Oshiro, N, Miyamoto, T, Takahashi, R, Avruch, J, Nakashima, A, Hara, K, Yoshino, K, Kikkawa, U, Eguchi, S
protein serine/threonine kinase activity of mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane]
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