Reactome | mTORC1 phosphorylates AKT1S1

mTORC1 phosphorylates AKT1S1

Stable Identifier

R-HSA-5672828

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal membrane, cytosol

ReviewStatus

5/5

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AKT1S1 (PRAS40) is phosphorylated by AKT at Thr246, which leads to the binding of YWHAB (14-3-3 beta) (Zhang et al. 2002, Kovacina et al. 2003. AKT1S1 is phosphorylated at Ser183 by mTORC1 (Oshiro et al. 2007); mutation of Ser183 decreases the affinity of AKT1S1 with YWHAB. As AKT1S1 suppresses mTORC1 phosphorylation of S6K1 and 4E-BP1 (Oshiro et al. 2007), binding of YWHAB is proposed to relieve this inhibition (Wang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
17517883	The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 Oshiro, N, Takahashi, R, Yoshino, K, Tanimura, K, Nakashima, A, Eguchi, S, Miyamoto, T, Hara, K, Takehana, K, Avruch, J, Kikkawa, U, Yonezawa, K	J Biol Chem	2007