Phosphorylated AKT1S1:mTORC1 binds YWHAB

Stable Identifier
R-HSA-5672824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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AKT1S1 (PRAS40) phosphorylation by AKT at Thr246, or at Ser183 by mTORC1, leads to the binding of YWHAB (14-3-3 beta) (Zhang et al. 2002, Kovacina et al. 2003, Oshiro et al. 2007). As AKT1S1 suppresses mTORC1 phosphorylation of physiological substrates S6K1 and 4E-BP1 (Oshiro et al. 2007) binding of YWHAB is proposed to relieve this inhibition (Wang et al. 2012).

Literature References
PubMed ID Title Journal Year
12151408 Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

Zhang, H, Zha, X, Tan, Y, Hornbeck, PV, Mastrangelo, AJ, Alessi, DR, Polakiewicz, RD, Comb, MJ

J. Biol. Chem. 2002
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