Reactome | PLEKHA3,8 bind PI4P, ARF1

PLEKHA3,8 bind PI4P, ARF1

Stable Identifier

R-HSA-8870499

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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Proteins with the plekstrin homology (PH) domain are able to bind specific phosphoinositides. Pleckstrin homology domain-containing family A members 3 and 8 (PLEKHA3 and PLEKHA8 aka FAPP1 and FAPP2) specifically bind phosphoinositide 4-phosphate (PI4P, PtdIns(4)P), a key intermediate in the synthesis of phosphoinositide 4,5-diphosphate (PIP2). PLEKHA3 and 8 are localised to the trans-Golgi network (TGN) where they interact with PI4P and the small GTPase ADP-ribosylation factor (ARF1) through their PH domains and mediate the transport of lipid cargo from the Golgi to the plasma membrane (Godi et al. 1999, Godi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
10559940	ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex Corda, D, Luini, A, Di Tullio, G, Godi, A, Iurisci, C, Pertile, P, Meyers, R, De Matteis, MA, Marra, P	Nat Cell Biol	1999
15107860	FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P Kular, GS, Daniele, T, Alessi, DR, Di Tullio, G, Konstantakopoulos, A, Godi, A, Lucocq, JM, Di Campli, A, De Matteis, MA, Marra, P	Nat Cell Biol	2004