AKT phosphorylates caspase-9

Stable Identifier
R-HSA-198621
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT phosphorylates caspase-9
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AKT can phosphorylate the apoptotic protease caspase-9, inhibiting it.
Literature References
PubMed ID Title Journal Year
9812896 Regulation of cell death protease caspase-9 by phosphorylation

Cardone, MH, Roy, N, Stennicke, HR, Salvesen, GS, Franke, TF, Stanbridge, E, Frisch, S, Reed, JC

Science 1998
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

Physical Entity
p-T,p-S-AKT [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT phosphorylates caspase-9 (Caenorhabditis elegans)
AKT phosphorylates caspase-9 (Danio rerio)
AKT phosphorylates caspase-9 (Drosophila melanogaster)
AKT phosphorylates caspase-9 (Gallus gallus)
AKT phosphorylates caspase-9 (Mus musculus)
AKT phosphorylates caspase-9 (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-06-29)
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