Reactome | APAF1 [cytosol]

APAF1 [cytosol]

Stable Identifier

R-HSA-50099

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Apaf-1, Apoptotic protease activating factor 1

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External Reference Information

External Reference

UniProt:O14727 APAF1

Gene Names

APAF1, KIAA0413

Chain

chain:1-1248

Reference Genes

BioGPS Gene:317 APAF1

COSMIC (genes):APAF1 APAF1

CTD Gene:317 APAF1

dbSNP Gene:317 APAF1

ENSEMBL:ENSG00000120868 APAF1

ENSEMBL_homo_sapiens_GENE:ENSG00000120868.14 APAF1

HGNC:576 APAF1

KEGG Gene (Homo sapiens):317 APAF1

Monarch:317 APAF1

NCBI Gene:317 APAF1

OMIM:602233 APAF1

UCSC:O14727 APAF1

Reference Transcript

Other Identifiers

11731156_x_at

11741240_a_at

11741241_a_at

11742201_a_at

16755542

204859_PM_s_at

204859_s_at

211553_PM_x_at

211553_x_at

211554_PM_s_at

211554_s_at

317

3427874

3427875

3427877

3427878

3427879

3427880

3427881

3427883

3427884

3427885

3427886

3427887

3427888

3427889

3427891

3427895

3427896

3427897

3427900

3427902

3427903

3427904

3427905

3427906

3427907

3427909

3427911

3427912

3427913

3427914

3427915

3427916

3427917

3427919

3427921

3427922

3427924

3427927

3427929

3427930

3427932

3427933

3427934

3427935

37227_at

7957759

A_14_P114248

A_14_P133794

A_23_P36611

GE80105

GO:0000166

GO:0001666

GO:0001822

GO:0001843

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0006915

GO:0006919

GO:0007399

GO:0007420

GO:0007584

GO:0008635

GO:0008656

GO:0010659

GO:0012501

GO:0023052

GO:0030154

GO:0030900

GO:0031072

GO:0031410

GO:0032991

GO:0034774

GO:0042802

GO:0042981

GO:0043065

GO:0043226

GO:0043293

GO:0043531

GO:0048856

GO:0051402

GO:0070059

GO:0070062

GO:0071560

GO:0072432

GO:0097190

GO:0097193

GO:0098772

GO:1902510

GO:1904813

GO:2001235

HMNXSV003004278

ILMN_1659463

ILMN_2344798

PH_hs_0024223

TC12000765.hg

g13506924_3p_a_at

g4929486_3p_a_at

g7108332_3p_a_at

Participates

as an output of

as a component of

Other forms of this molecule

APAF1 [secretory granule lumen]

APAF1 [extracellular region]

APAF1 [ficolin-1-rich granule lumen]

Inferred To

Dark [cytosol] (Drosophila melanogaster)

APAF1 [cytosol] (Bos taurus)

APAF1 [cytosol] (Canis familiaris)

APAF1 [cytosol] (Danio rerio)

APAF1 [cytosol] (Gallus gallus)

APAF1 [cytosol] (Mus musculus)

APAF1 [cytosol] (Rattus norvegicus)

APAF1 [cytosol] (Sus scrofa)

apaf1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_863658.1, NP_037361.1, NP_863651.1, NP_001151.1, NP_863659.1

OpenTargets

ENSG00000120868

HPA

ENSG00000120868-APAF1

GeneCards

O14727

Ensembl

ENST00000333991, ENST00000359972, ENSG00000120868, ENST00000552268, ENST00000551964, ENSP00000448449, ENSP00000448826, ENSP00000334558, ENSP00000353059, ENST00000357310, ENSP00000349862, ENST00000547045, ENST00000550527, ENSP00000449791, ENSP00000448165

PRO

O14727

Pharos - Targets

O14727

HMDB Protein

HMDBP02284

PDB

2YGS, 2P1H, 3J2T, 1Z6T, 4RHW, 3YGS, 1CWW, 1C15, 5WVC, 1CY5, 5JUY, 5WVE, 3JBT

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55211 CASP9	5	p-S196-CASP9(1-416) [cytosol] (R-HSA-198636) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) CASP9(331-416) [cytosol] (R-HSA-141639) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(1-416) [cytosol] (R-HSA-57033)	0.964	25
UniProt:P62894	6	AcK-CYCS [mitochondrial intermembrane space] (R-BTA-5688308) apo-CYCS [mitochondrial inner membrane] (R-BTA-352608) Cytochrome c (reduced) [mitochondrial inner membrane] (R-BTA-352609) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-BTA-352607) CYCS [mitochondrial intermembrane space] (R-BTA-114244) CYCS [cytosol] (R-BTA-53259)	0.736	14
UniProt:P99999 CYCS	6	AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308) apo-CYCS [mitochondrial inner membrane] (R-HSA-352608) Cytochrome c (reduced) [mitochondrial inner membrane] (R-HSA-352609) CYCS [cytosol] (R-HSA-53259) CYCS [mitochondrial intermembrane space] (R-HSA-114244) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-HSA-352607)	0.688	6
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.653	7
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:Q9Z0F3 B2L10			0.508	2