Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Tiam1 [cytosol]
Stable Identifier
R-MMU-9033323
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
T-lymphoma invasion and metastasis-inducing protein 1, TIAM1_MOUSE
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPH-ephrin mediated repulsion of cells (Mus musculus)
EPHA binds TIAM1 (Mus musculus)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
EPHB phosphorylates TIAM1 (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
EPHB:NMDAR binds TIAM1 (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRAGE signals death through JNK (Mus musculus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
GEFs [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
GEFs activate RhoA,B,C (Mus musculus)
GEFs [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
CDC42 GTPase cycle (Mus musculus)
CDC42 GEFs activate CDC42 (Mus musculus)
CDC42 GEFs [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 GEFs activate RAC1 (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
RAC2 GTPase cycle (Mus musculus)
RAC2 GEFs activate RAC2 (Mus musculus)
RAC2 GEFs [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
RAC3 GTPase cycle (Mus musculus)
RAC3 GEFs activate RAC3 (Mus musculus)
RAC3 GEFs [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
RHOA GTPase cycle (Mus musculus)
RHOA GEFs activate RHOA (Mus musculus)
RHOA GEFs [cytosol] (Mus musculus)
Tiam1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60610 Tiam1
Gene Names
Tiam1, Tiam-1
Chain
initiator methionine:, chain:2-1591
Reference Genes
UCSC:Q60610 Tiam1
Participates
as a candidate of
RHOA GEFs [cytosol] (Mus musculus)
CDC42 GEFs [cytosol] (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
as a member of
RAC2 GEFs [cytosol] (Mus musculus)
RAC3 GEFs [cytosol] (Mus musculus)
GEFs [cytosol] (Mus musculus)
as an input of
EPHB:NMDAR binds TIAM1 (Mus musculus)
EPHA binds TIAM1 (Mus musculus)
Ntrk2 binds Tiam1 (Mus musculus)
as a component of
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
BDNF:p-5Y,S478-Ntrk2 homodimer:Tiam1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y829-Tiam1 [cytosol]
Inferred From
TIAM1 [cytosol]
(Homo sapiens)
Cross References
PRO
Q60610
MGI
103306
PDB
7UIQ
,
3A8N
,
1FOE
,
7UIR
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text