EPHB:NMDAR binds TIAM1

Stable Identifier
R-HSA-3928645
Type
Reaction [binding]
Species
Homo sapiens
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T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a Rac1-specific GEF, highly expressed in the nervous system, which is necessary for proper spinal and synapse development. It is one of the critical mediators of NMDA receptor (NMDAR)-dependent spine development (Tolias et al. 2005). TIAM1 might also play a role in regulating EPHB-dependent spine morphogenesis. TIAM1 appears to be required for ephrinB (EFNB)-induced increase in spine density. TIAM1 is recruited to EPHB complexes containing NMDAR after EPHB receptor activation in neurons. The PH-CC-Ex (consisting of a pleckstrin homology (PH) domain followed by a coiled-coiled (CC) domain and an adjacent region (Ex) domain) of TIAM1 is required for binding to EPHB2 (Tolias et al. 2007).

Literature References
PubMed ID Title Journal Year
14988728 Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2

Tanaka, M, Ohashi, R, Nakamura, R, Shinmura, K, Kamo, T, Sakai, R, Sugimura, H

EMBO J. 2004
17440041 The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

Tolias, KF, Bikoff, JB, Kane, CG, Tolias, CS, Hu, L, Greenberg, ME

Proc. Natl. Acad. Sci. U.S.A. 2007
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