Dissociation of paradoxically activated RAS:BRAF complexes

Stable Identifier
R-HSA-6803234
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
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Dissociation of paradoxically activated RAS:BRAF complexes
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After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by kinase dead or inhibited BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).

Literature References
PubMed ID Title Journal Year
25907612 Regulation of RAF protein kinases in ERK signalling

Lavoie, H, Therrien, M

Nat. Rev. Mol. Cell Biol. 2015
Participants
Input
Output
Participant Of
hasEvent
Normal reaction
Dissociation of RAS:RAF complex (Homo sapiens)
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2015-08-10)
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2015-10-05)