Dissociation of paradoxically activated RAS:BRAF complexes

Stable Identifier
R-HSA-6803234
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Dissociation of paradoxically activated RAS:BRAF complexes
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After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by kinase dead or inhibited BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).
Literature References
PubMed ID Title Journal Year
25907612 Regulation of RAF protein kinases in ERK signalling

Lavoie, H, Therrien, M

Nat. Rev. Mol. Cell Biol. 2015
Participants
Input
Output
Participates
as an event of
Normal reaction
Dissociation of RAS:RAF complex (Homo sapiens)
Functional status

Gain of function of RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2015-08-10)
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2015-10-05)
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