After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by highly active BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).
Lavoie, H, Therrien, M
Gain of function of high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol]
© 2023 Reactome