Dissociation of high activity BRAF complexes

Stable Identifier
R-HSA-6803227
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Dissociation of high activity BRAF complexes
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After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by highly active BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).

Literature References
PubMed ID Title Journal Year
25907612 Regulation of RAF protein kinases in ERK signalling

Lavoie, H, Therrien, M

Nat. Rev. Mol. Cell Biol. 2015
Participants
Input
Output
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as an event of
Normal reaction
Dissociation of RAS:RAF complex (Homo sapiens)
Functional status

Gain of function of high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cardiofaciocutaneous syndrome DOID:0060233 CFC syndrome, cardio-facial-cutaneous syndrome
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2015-08-10)
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2015-10-05)
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