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phospho-p-T185,Y187-MAPK1 [cytosol]
Stable Identifier
R-XTR-109853
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
Q28H11
Locations in the PathwayBrowser
Expand all
Cell Cycle (Xenopus tropicalis)
Cell Cycle, Mitotic (Xenopus tropicalis)
M Phase (Xenopus tropicalis)
Mitotic Prophase (Xenopus tropicalis)
Golgi Cisternae Pericentriolar Stack Reorganization (Xenopus tropicalis)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)
p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Developmental Biology (Xenopus tropicalis)
MITF-M-regulated melanocyte development (Xenopus tropicalis)
Transcriptional and post-translational regulation of MITF-M expression and activity (Xenopus tropicalis)
MAPK1 phosphorylates SOX10 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
MAPK1-dependent phosphorylation of MITF-M (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Nervous system development (Xenopus tropicalis)
Axon guidance (Xenopus tropicalis)
L1CAM interactions (Xenopus tropicalis)
Recycling pathway of L1 (Xenopus tropicalis)
Phosphorylation of L1 by ERK (Xenopus tropicalis)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by NODAL (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Xenopus tropicalis)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Hemostasis (Xenopus tropicalis)
Platelet activation, signaling and aggregation (Xenopus tropicalis)
Thrombin signalling through proteinase activated receptors (PARs) (Xenopus tropicalis)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Xenopus tropicalis)
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Immune System (Xenopus tropicalis)
Cytokine Signaling in Immune system (Xenopus tropicalis)
Interferon Signaling (Xenopus tropicalis)
Interferon gamma signaling (Xenopus tropicalis)
JAK2-activated MAPKs phosphorylate YBX1 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Fcgamma receptor (FCGR) dependent phagocytosis (Xenopus tropicalis)
Regulation of actin dynamics for phagocytic cup formation (Xenopus tropicalis)
p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Programmed Cell Death (Xenopus tropicalis)
Apoptosis (Xenopus tropicalis)
Intrinsic Pathway for Apoptosis (Xenopus tropicalis)
Apoptotic factor-mediated response (Xenopus tropicalis)
Cytochrome c-mediated apoptotic response (Xenopus tropicalis)
Formation of apoptosome (Xenopus tropicalis)
Regulation of the apoptosome activity (Xenopus tropicalis)
CASP9 is phosphorylated at T412 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF-independent MAPK1/3 activation (Xenopus tropicalis)
Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Phosphorylated MAPKs translocate into the nucleus (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
p-T,Y MAPKs dimerize (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
Negative regulation of MAPK pathway (Xenopus tropicalis)
Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Negative feedback regulation of MAPK pathway (Xenopus tropicalis)
Activated MAPK phosphorylates RAF1 (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Phosphorylated MAPKs translocate into the nucleus (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Xenopus tropicalis)
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
p-T,Y MAPKs dimerize (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Opioid Signalling (Xenopus tropicalis)
G-protein mediated events (Xenopus tropicalis)
PLC beta mediated events (Xenopus tropicalis)
Ca-dependent events (Xenopus tropicalis)
phospho-PLA2 pathway (Xenopus tropicalis)
Phosphorylation of cPLA2 by ERK-2 (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by Nuclear Receptors (Xenopus tropicalis)
ESR-mediated signaling (Xenopus tropicalis)
Extra-nuclear estrogen signaling (Xenopus tropicalis)
Estrogen-stimulated signaling through PRKCZ (Xenopus tropicalis)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by FGFR (Xenopus tropicalis)
Signaling by FGFR1 (Xenopus tropicalis)
Negative regulation of FGFR1 signaling (Xenopus tropicalis)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by FGFR2 (Xenopus tropicalis)
Negative regulation of FGFR2 signaling (Xenopus tropicalis)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by FGFR3 (Xenopus tropicalis)
Negative regulation of FGFR3 signaling (Xenopus tropicalis)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by FGFR4 (Xenopus tropicalis)
Negative regulation of FGFR4 signaling (Xenopus tropicalis)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
Signalling to ERKs (Xenopus tropicalis)
Prolonged ERK activation events (Xenopus tropicalis)
Frs2-mediated activation (Xenopus tropicalis)
p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
p-T,Y MAPKs dimerize (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
Signaling by Rho GTPases (Xenopus tropicalis)
RHO GTPase Effectors (Xenopus tropicalis)
RHO GTPases Activate NADPH Oxidases (Xenopus tropicalis)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
RHO GTPases Activate WASPs and WAVEs (Xenopus tropicalis)
p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by TGFB family members (Xenopus tropicalis)
Signaling by Activin (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
Signaling by TGF-beta Receptor Complex (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Xenopus tropicalis)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
phospho-p-T185,Y187-MAPK1 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:Q28H11
Reference Genes
BioGPS Gene:549881
ENSEMBL:ENSXETG00000018576
KEGG:xtr:549881
Monarch:549881
NCBI Gene:549881
UCSC:Q28H11
Reference Transcript
RefSeq:NM_001017127.2
Other Identifiers
549881
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005524
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005856
GO:0006915
GO:0007166
GO:0016301
GO:0016740
GO:0035556
GO:0043226
GO:0140096
Participates
as a component of
F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] (Xenopus tropicalis)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Xenopus tropicalis)
p-T185,Y187 MAPK1 dimer [cytosol] (Xenopus tropicalis)
as an input of
Phosphorylation of L1 by ERK (Xenopus tropicalis)
p-T,Y MAPKs dimerize (Xenopus tropicalis)
as a member of
p-T,Y MAPK monomers and dimers [cytosol] (Xenopus tropicalis)
Other forms of this molecule
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
MAPK1 [nucleoplasm]
MAPK1 [cytosol]
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
Inferred From
p-T,Y MAPKs [cytosol]
(Homo sapiens)
p-T185,Y187-MAPK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 185 (in Homo sapiens)
Coordinate
185
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENSXETT00000073723
,
ENSXETP00000079571
,
ENSXETG00000018576
Xenbase
XB-GENE-479467
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