Lyn activates ERK

Stable Identifier
Reaction [omitted]
Homo sapiens
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The activation of Lyn by GHR is thought to indirectly activate ERK. Mutations of GHR predicted to disable a conformational change brought about by GH binding impaired ERK signaling but not JAK2/STAT5 signaling. ERK signaling was demonstrated to involve the Src family kinase Lyn (Rowlinson et al. 2008) and suggested to involve Src kinase dependent activation of Phospholipase C gamma and thereby Ras, similar to a mechanism proposed by Bivona et al. (2003). ERK activation mechanisms involving Src kinases and PLCgamma have been reported for the erythropoietin, thrombopoietin and prolactin receptors (Brooks & Waters 2010).

Literature References
PubMed ID Title Journal Year
18488018 An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

Rowlinson, SW, Millard, K, Clyde-Smith, J, Nielsen, K, Palethorpe, K, Waters, MJ, Brooks, AJ, Kerr, LM, Hancock, JF, Behncken, SN, Barclay, JL, Yoshizato, H

Nat Cell Biol 2008
Catalyst Activity

non-membrane spanning protein tyrosine kinase activity of Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane]

Orthologous Events
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