Dissociation of oncogenic RAS:RAF complex

Stable Identifier
R-HSA-6803233
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Dissociation of oncogenic RAS:RAF complex
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After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by oncogenic RAS presumably dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015; Stephen et al, 2014).
Literature References
PubMed ID Title Journal Year
25907612 Regulation of RAF protein kinases in ERK signalling

Lavoie, H, Therrien, M

Nat. Rev. Mol. Cell Biol. 2015
24651010 Dragging ras back in the ring

Stephen, AG, Esposito, D, Bagni, RK, McCormick, F

Cancer Cell 2014
Participants
Input
Output
Participates
as an event of
Normal reaction
Dissociation of RAS:RAF complex (Homo sapiens)
Functional status

Gain of function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Noonan syndrome DOID:3490 Turner's phenotype, karyotype normal (disorder)
Cross References
Mondo
Authored
Rothfels, K  (2015-08-10)
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2015-10-05)
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