Dissociation of oncogenic RAS:RAF complex

Stable Identifier
R-HSA-6803233
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by oncogenic RAS presumably dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015; Stephen et al, 2014).

Literature References
PubMed ID Title Journal Year
24651010 Dragging ras back in the ring

Stephen, AG, Esposito, D, Bagni, RK, McCormick, F

Cancer Cell 2014
25907612 Regulation of RAF protein kinases in ERK signalling

Lavoie, H, Therrien, M

Nat. Rev. Mol. Cell Biol. 2015
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
Noonan syndrome 3490 Turner's phenotype, karyotype normal (disorder)
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created