Dissociation of RAS:RAF1 mutant complex

Stable Identifier
R-HSA-9656209
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dissociation of RAS:RAF1 mutant complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After phosphorylation of MAPKs by complexes containing RAF1 mutants, activated MAPK signaling complexes dissociate in a manner similar to wildtype, although this has not been explicitly demonstrated in all cases. Active complexes may signal from other cellular locations or may amplify signaling through rounds of heterodimerization with other inactive RAF monomers (reviewed in Matallanas et al, 2011; Cseh et al, 2014).
Literature References
PubMed ID Title Journal Year
24937142 "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway

Cseh, B, Doma, E, Baccarini, M

FEBS Lett. 2014
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
Participants
Input
Output
Participates
as an event of
Normal reaction
Dissociation of RAS:RAF complex (Homo sapiens)
Functional status

Gain of function of activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
Costello syndrome DOID:0050469 Faciocutaneoskeletal Syndrome, FCS SYNDROME
LEOPARD syndrome DOID:14291 Generalized lentiginosis, Multiple lentigines syndrome, Moynahan syndrome, Cardiocutaneous syndrome, Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome, Lentiginosis profusa syndrome, Gorlin syndrome II, Progressive cardiomyopathic lentiginosis
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Noonan syndrome DOID:3490 Turner's phenotype, karyotype normal (disorder)
hypertrophic cardiomyopathy DOID:11984 familial hypertrophic cardiomyopathy, hypertrophic obstructive cardiomyopathy
Cross References
Mondo
Authored
Rothfels, K  (2019-10-25)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Rothfels, K  (2019-07-27)
Cite Us!