After phosphorylation of MAPKs by complexes containing RAF1 mutants, activated MAPK signaling complexes dissociate in a manner similar to wildtype, although this has not been explicitly demonstrated in all cases. Active complexes may signal from other cellular locations or may amplify signaling through rounds of heterodimerization with other inactive RAF monomers (reviewed in Matallanas et al, 2011; Cseh et al, 2014).
Baccarini, M, Cseh, B, Doma, E
Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A
Gain of function of activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
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