Phosphorylation of MEK4 by MEKK1

Stable Identifier
R-HSA-2730896
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Phosphorylation of MEK4 by MEKK1
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Activated MEKK1 then phosphorylates and activates SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK) on serine and threonine residues at positions 257 and 261, respectively.

Literature References
PubMed ID Title Journal Year
7855889 MAPKs: new JNK expands the group

Davis, RJ

Trends Biochem. Sci. 1994
7997270 Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

Yan, M, Dai, T, Deak, JC, Kyriakis, JM, Zon, LI, Woodgett, JR, Templeton, DJ

Nature 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T1400,T1412-MAP3K1 [cytosol]
Physical Entity
p-T1400,T1412-MAP3K1 [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Phosphorylation of MEK4 by MEKK1 (Bos taurus)
Phosphorylation of MEK4 by MEKK1 (Canis familiaris)
Phosphorylation of MEK4 by MEKK1 (Danio rerio)
Phosphorylation of MEK4 by MEKK1 (Gallus gallus)
Phosphorylation of MEK4 by MEKK1 (Mus musculus)
Phosphorylation of MEK4 by MEKK1 (Rattus norvegicus)
Phosphorylation of MEK4 by MEKK1 (Sus scrofa)
Phosphorylation of MEK4 by MEKK1 (Xenopus tropicalis)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)