MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)

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R-HSA-3229152
Type
Reaction [transition]
Species
Homo sapiens
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MAP3K5 (ASK1) phosphorylates and activates MAP2K4 (SEK1) (Ichijo et al. 1997). MAP3K5-mediated phosphorylation of MAP2K4 may be facilitated by MAPK8IP3 (JSAP1) (Matsuura et al. 2002).

Literature References
PubMed ID Title Journal Year
8974401 Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

Ichijo, H, Nishida, E, Irie, K, ten Dijke, P, Saitoh, M, Moriguchi, T, Takagi, M, Matsumoto, K, Miyazono, K, Gotoh, Y

Science 1997
12189133 Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade

Matsuura, H, Nishitoh, H, Takeda, K, Matsuzawa, A, Amagasa, T, Ito, M, Yoshioka, K, Ichijo, H

J. Biol. Chem. 2002
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Catalyst Activity
Title
protein serine/threonine kinase activity of MAP3K5 [cytosol]
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