Reactome | MAP2K4 [cytosol]

MAP2K4 [cytosol]

Stable Identifier

R-XTR-168107

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

A9UM81

Locations in the PathwayBrowser

Expand all

Immune System (Xenopus tropicalis)

- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-17 signaling (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
    - FCERI mediated MAPK activation (Xenopus tropicalis)
      - Phosphorylation of MEK4 by MEKK1 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
  - Toll-like Receptor Cascades (Xenopus tropicalis)
    - Toll Like Receptor 10 (TLR10) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
    - Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
      - Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
      - Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
    - Toll Like Receptor 3 (TLR3) Cascade (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
    - Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
      - MyD88-independent TLR4 cascade (Xenopus tropicalis)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
    - Toll Like Receptor 5 (TLR5) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)
    - Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Xenopus tropicalis)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)
        
        MAP2K4 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A9UM81

Reference Genes

BioGPS Gene:100135013

ENSEMBL:ENSXETG00000011036

KEGG Gene (Xenopus tropicalis):100135013

Monarch:100135013

NCBI Gene:100135013

Reference Transcript

RefSeq:NM_001113685.1

Participates

as an input of

Other forms of this molecule

phospho-p-S257,T261-MAP2K4 [cytosol]

Inferred From

MAP2K7,MAP2K4 [cytosol] (Homo sapiens)

MAP2K4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001107157.1

Xenbase

XB-GENE-482151