Reactome | MAP2K4 [cytosol]

MAP2K4 [cytosol]

Stable Identifier

R-CFA-168107

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

A0A8I3MIB2

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Phosphorylation of MEK4 by MEKK1 (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        MAP2K7,MAP2K4 [cytosol] (Canis familiaris)
        
        MAP2K4 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MIB2

Reference Genes

ENSEMBL:ENSCAFG00845003515.1

UCSC:A0A8I3MIB2

Other Identifiers

489508

Cfa.11004.1.A1_at

CfaAffx.27320.1.S1_at

CfaAffx.27320.1.S1_s_at

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004713

GO:0005524

GO:0005829

GO:0006468

GO:0009611

GO:0016301

GO:0016740

GO:0033554

GO:0034390

GO:0036481

GO:0071260

GO:0140096

GO:2000672

Participates

as an input of

Phosphorylation of MEK4 by MEKK1 (Canis familiaris)

as a member of

MAP2K7,MAP2K4 [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-p-S257,T261-MAP2K4 [cytosol]

Inferred From

MAP2K4 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845004998, ENSCAFT00845006293, ENSCAFG00845003515

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