Reactome | abi2 [cytosol]

abi2 [cytosol]

Stable Identifier

R-XTR-1671647

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

ABI2, Q28HT5

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Innate Immune System (Xenopus tropicalis)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Xenopus tropicalis)
    - Regulation of actin dynamics for phagocytic cup formation (Xenopus tropicalis)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
      - ABL phosphorylates WAVEs (Xenopus tropicalis)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        WAVE Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
      - Detachment of WASP/WAVE (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
      - p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
  - Signaling by Rho GTPases (Xenopus tropicalis)
    - RHO GTPase Effectors (Xenopus tropicalis)
      - RHO GTPases Activate WASPs and WAVEs (Xenopus tropicalis)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        ABL phosphorylates WAVEs (Xenopus tropicalis)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        WAVE Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        Detachment of WASP/WAVE (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-Y-WRC [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
    - RHO GTPase cycle (Xenopus tropicalis)
      - RAC1 GTPase cycle (Xenopus tropicalis)
        
        RAC1 binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RAC1 effectors [cytosol] (Xenopus tropicalis)
        
        WAVE Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Xenopus tropicalis)
        
        RAC1 effectors [cytosol] (Xenopus tropicalis)
        
        WAVE Regulatory Complex [cytosol] (Xenopus tropicalis)
        
        ABI [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
      - RAC2 GTPase cycle (Xenopus tropicalis)
        
        RAC2 binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RAC2 plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Xenopus tropicalis)
        
        RAC2 plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
      - RAC3 GTPase cycle (Xenopus tropicalis)
        
        RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RAC3 effectors [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)
        
        RAC3:GTP:RAC3 effectors [plasma membrane] (Xenopus tropicalis)
        
        RAC3 effectors [cytosol] (Xenopus tropicalis)
        
        abi2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q28HT5

Gene Names

abi2

Reference Genes

BioGPS Gene:548798 abi2

ENSEMBL:ENSXETG00000004155

KEGG Gene (Xenopus tropicalis):548798 abi2

Monarch:548798 abi2

NCBI Gene:548798 abi2

Reference Transcript

RefSeq:NM_001016044.2 abi2

Participates

as a candidate of

Other forms of this molecule

phospho-abi2 [cytosol]

Inferred From

ABI2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001016044.1

Xenbase

XB-GENE-944589

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