Reactome | ABI2 [cytosol]

ABI2 [cytosol]

Stable Identifier

R-CFA-1671647

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ABI2, A0A8I3P8Q3

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
      - ABL phosphorylates WAVEs (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
      - Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
      - p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase Effectors (Canis familiaris)
      - RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        ABL phosphorylates WAVEs (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RAC1 GTPase cycle (Canis familiaris)
        
        RAC1 binds effectors at the plasma membrane (Canis familiaris)
        
        RAC1 effectors [cytosol] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
        
        RAC1 effectors [cytosol] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
      - RAC2 GTPase cycle (Canis familiaris)
        
        RAC2 binds effectors at the plasma membrane (Canis familiaris)
        
        RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Canis familiaris)
        
        RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
      - RAC3 GTPase cycle (Canis familiaris)
        
        RAC3 binds effectors at the plasma membrane (Canis familiaris)
        
        RAC3 effectors [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE1 Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        RAC3:GTP:RAC3 effectors [plasma membrane] (Canis familiaris)
        
        RAC3 effectors [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE1 Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P8Q3

Gene Names

ABI2

Reference Genes

ENSEMBL:ENSCAFG00845016661.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016661.1 ABI2

Other Identifiers

488485

Cfa.1679.1.A1_at

Cfa.7090.1.S1_s_at

CfaAffx.19895.1.S1_at

CfaAffx.19895.1.S1_s_at

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0005856

GO:0030027

GO:0030175

GO:0042995

GO:0043226

GO:0043231

GO:0110165

Participates

as a candidate of

Other forms of this molecule

phospho-ABI2 [cytosol]

Inferred From

ABI2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000138443

Ensembl

ENSCAFT00845029581, ENSCAFG00845016661, ENSCAFP00845023233

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