Reactome | Regulation of gene expression by Hypoxia-inducible Factor

Regulation of gene expression by Hypoxia-inducible Factor

Stable Identifier

R-HSA-1234158

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Regulation of gene expression by Hypoxia-inducible Factor

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HIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) is translocated to the nucleus, possibly by two pathways: importin 4/7 (Chachami et al. 2009) and importin alpha/beta (Depping et al. 2008). Once in the nucleus HIF-alpha heterodimerizes with HIF-beta (ARNT) (Wang et al. 1995, Jiang et al. 1996, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003) and recruits CBP and p300 to promoters of target genes (Ebert and Bunn 1998, Kallio et al. 1998, Ema et al. 1999, Gu et al. 2001, Dames et al. 2002, Freedman et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
7539918	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Wang, GL, Jiang, BH, Rue, EA, Semenza, GL	Proc Natl Acad Sci U S A	1995
9000051	Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells Tian, H, McKnight, SL, Russell, DW	Genes Dev	1997
10202154	Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 Ema, M, Hirota, K, Mimura, J, Abe, H, Yodoi, J, Sogawa, K, Poellinger, L, Fujii-Kuriyama, Y	EMBO J	1999
19788888	Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7 Chachami, G, Paraskeva, E, Mingot, JM, Braliou, GG, Görlich, D, Simos, G	Biochem Biophys Res Commun	2009
9840812	Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha Gu, YZ, Moran, SM, Hogenesch, JB, Wartman, L, Bradfield, CA	Gene Expr	1998
9822602	Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha Kallio, PJ, Okamoto, K, O'Brien, S, Carrero, P, Makino, Y, Tanaka, H, Poellinger, L	EMBO J	1998
9632793	Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein Ebert, BL, Bunn, HF	Mol Cell Biol	1998
18187047	Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway Depping, R, Steinhoff, A, Schindler, SG, Friedrich, B, Fagerlund, R, Metzen, E, Hartmann, E, Köhler, M	Biochim Biophys Acta	2008
14668441	Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor Erbel, PJ, Card, PB, Karakuzu, O, Bruick, RK, Gardner, KH	Proc Natl Acad Sci U S A	2003
11959990	Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha Freedman, SJ, Sun, ZY, Poy, F, Kung, AL, Livingston, DM, Wagner, G, Eck, MJ	Proc Natl Acad Sci U S A	2002
8663540	Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 Jiang, BH, Rue, E, Wang, GL, Roe, R, Semenza, GL	J Biol Chem	1996
11959977	Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response Dames, SA, Martinez-Yamout, M, De Guzman, RN, Dyson, HJ, Wright, PE	Proc Natl Acad Sci U S A	2002
11063749	Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine Gu, J, Milligan, J, Huang, LE	J Biol Chem	2001