Expression of Erythropoietin (EPO)

Stable Identifier
Reaction [omitted]
Homo sapiens
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The EPO gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of EPO is enhanced by Hypoxia-inducible factor, which binds to the EPO promoter.

Literature References
PubMed ID Title Journal Year
8663540 Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

Jiang, BH, Rue, E, Wang, GL, Roe, R, Semenza, GL

J Biol Chem 1996
7836384 Purification and characterization of hypoxia-inducible factor 1

Wang, GL, Semenza, GL

J Biol Chem 1995
8387214 General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

Wang, GL, Semenza, GL

Proc Natl Acad Sci U S A 1993
8917528 An essential role for p300/CBP in the cellular response to hypoxia

Arany, Z, Huang, LE, Eckner, R, Bhattacharya, S, Jiang, C, Goldberg, MA, Bunn, HF, Livingston, DM

Proc Natl Acad Sci U S A 1996
9027736 Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors

Huang, LE, Ho, V, Arany, Z, Krainc, D, Galson, D, Tendler, D, Livingston, DM, Bunn, HF

Kidney Int 1997
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