Expression of Erythropoietin (EPO)

Stable Identifier
R-HSA-1235070
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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Expression of Erythropoietin (EPO)
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The EPO gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of EPO is enhanced by Hypoxia-inducible factor, which binds to the EPO promoter.

The HIF heterodimer binds the promoter of the EPO gene and recruits p300 and CBP to enhance transcription of EPO.

Literature References
PubMed ID Title Journal Year
7836384 Purification and characterization of hypoxia-inducible factor 1

Semenza, GL, Wang, GL

J Biol Chem 1995
8663540 Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

Semenza, GL, Rue, E, Wang, GL, Jiang, BH, Roe, R

J Biol Chem 1996
8387214 General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

Semenza, GL, Wang, GL

Proc Natl Acad Sci U S A 1993
8917528 An essential role for p300/CBP in the cellular response to hypoxia

Livingston, DM, Goldberg, MA, Eckner, R, Jiang, C, Arany, Z, Huang, LE, Bhattacharya, S, Bunn, HF

Proc Natl Acad Sci U S A 1996
9027736 Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors

Livingston, DM, Krainc, D, Arany, Z, Ho, V, Tendler, D, Huang, LE, Bunn, HF, Galson, D

Kidney Int 1997
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
HIF:CBP:p300 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-03-20)
Reviewed
Rantanen, K  (2012-05-19)
Created
May, B  (2011-03-21)
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