HIF-alpha is translocated into the nucleus (Kallio et al. 1998, Depping et al. 2008, Chachami et al. 2009). Importin 4 and importin 7 (Chachami et al. 2009) as well as the importin alpha/beta pathway (Depping et al. 2008) appear to be capable of interacting with HIF-alpha. During hypoxia HIF-alpha accumulates in the nucleus where it associates with CBP and p300 (Kallio et al. 1998).
Chachami, G, Paraskeva, E, Mingot, JM, Braliou, GG, Görlich, D, Simos, G
Depping, R, Steinhoff, A, Schindler, SG, Friedrich, B, Fagerlund, R, Metzen, E, Hartmann, E, Köhler, M
Kallio, PJ, Okamoto, K, O'Brien, S, Carrero, P, Makino, Y, Tanaka, H, Poellinger, L
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