HIF-alpha (HIF1A, EPAS1, HIF3A isoform 1) is translocated into the nucleus (Kallio et al. 1998, Depping et al. 2008, Chachami et al. 2009, Heikkilä et al. 2011). Importin 4 and importin 7 (Chachami et al. 2009) as well as the importin alpha/beta pathway (Depping et al. 2008) appear to be capable of interacting with HIF-alpha. During hypoxia HIF-alpha accumulates in the nucleus where it associates with CBP and p300 (Kallio et al. 1998).
Steinhoff, A, Depping, R, Fagerlund, R, Metzen, E, Hartmann, E, Friedrich, B, Köhler, M, Schindler, SG
Myllyharju, J, Heikkilä, M, Kivirikko, KI, Pasanen, A
Simos, G, Paraskeva, E, Görlich, D, Braliou, GG, Chachami, G, Mingot, JM
Carrero, P, O'Brien, S, Poellinger, L, Kallio, PJ, Okamoto, K, Tanaka, H, Makino, Y
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