HIF-alpha translocates from cytosol to nucleus

Stable Identifier
R-HSA-1234161
Type
Reaction [omitted]
Species
Homo sapiens
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HIF-alpha is translocated into the nucleus (Kallio et al. 1998, Depping et al. 2008, Chachami et al. 2009). Importin 4 and importin 7 (Chachami et al. 2009) as well as the importin alpha/beta pathway (Depping et al. 2008) appear to be capable of interacting with HIF-alpha. During hypoxia HIF-alpha accumulates in the nucleus where it associates with CBP and p300 (Kallio et al. 1998).

Literature References
PubMed ID Title Journal Year
19788888 Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7

Chachami, G, Paraskeva, E, Mingot, JM, Braliou, GG, Görlich, D, Simos, G

Biochem Biophys Res Commun 2009
18187047 Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway

Depping, R, Steinhoff, A, Schindler, SG, Friedrich, B, Fagerlund, R, Metzen, E, Hartmann, E, Köhler, M

Biochim Biophys Acta 2008
9822602 Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

Kallio, PJ, Okamoto, K, O'Brien, S, Carrero, P, Makino, Y, Tanaka, H, Poellinger, L

EMBO J 1998
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