HIF-alpha translocates from cytosol to nucleus

Stable Identifier
Reaction [omitted]
Homo sapiens
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HIF-alpha (HIF1A, EPAS1, HIF3A isoform 1) is translocated into the nucleus (Kallio et al. 1998, Depping et al. 2008, Chachami et al. 2009, Heikkilä et al. 2011). Importin 4 and importin 7 (Chachami et al. 2009) as well as the importin alpha/beta pathway (Depping et al. 2008) appear to be capable of interacting with HIF-alpha. During hypoxia HIF-alpha accumulates in the nucleus where it associates with CBP and p300 (Kallio et al. 1998).

Literature References
PubMed ID Title Journal Year
18187047 Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway

Steinhoff, A, Depping, R, Fagerlund, R, Metzen, E, Hartmann, E, Friedrich, B, Köhler, M, Schindler, SG

Biochim Biophys Acta 2008
21479871 Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

Myllyharju, J, Heikkilä, M, Kivirikko, KI, Pasanen, A

Cell Mol Life Sci 2011
19788888 Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7

Simos, G, Paraskeva, E, Görlich, D, Braliou, GG, Chachami, G, Mingot, JM

Biochem Biophys Res Commun 2009
9822602 Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

Carrero, P, O'Brien, S, Poellinger, L, Kallio, PJ, Okamoto, K, Tanaka, H, Makino, Y

EMBO J 1998
Orthologous Events
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