Reactome | HIF-alpha translocates from cytosol to nucleus

HIF-alpha translocates from cytosol to nucleus

Stable Identifier

R-HSA-1234161

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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HIF-alpha translocates from cytosol to nucleus

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HIF-alpha (HIF1A, EPAS1, HIF3A isoform 1) is translocated into the nucleus (Kallio et al. 1998, Depping et al. 2008, Chachami et al. 2009, Heikkilä et al. 2011). Importin 4 and importin 7 (Chachami et al. 2009) as well as the importin alpha/beta pathway (Depping et al. 2008) appear to be capable of interacting with HIF-alpha. During hypoxia HIF-alpha accumulates in the nucleus where it associates with CBP and p300 (Kallio et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
18187047	Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway Steinhoff, A, Depping, R, Fagerlund, R, Metzen, E, Hartmann, E, Friedrich, B, Köhler, M, Schindler, SG	Biochim Biophys Acta	2008
21479871	Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response Myllyharju, J, Heikkilä, M, Kivirikko, KI, Pasanen, A	Cell Mol Life Sci	2011
19788888	Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7 Simos, G, Paraskeva, E, Görlich, D, Braliou, GG, Chachami, G, Mingot, JM	Biochem Biophys Res Commun	2009
9822602	Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha Carrero, P, O'Brien, S, Poellinger, L, Kallio, PJ, Okamoto, K, Tanaka, H, Makino, Y	EMBO J	1998