Reactome | Formation of HIF:CBP:p300 complex at promoters

Formation of HIF:CBP:p300 complex at promoters

Stable Identifier

R-HSA-1234167

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Formation of HIF:CBP:p300 complex at promoters

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HIF (heterodimer of HIF-alpha and HIF-beta) recruits p300 and CBP to the promoters of target genes (Kallio et al. 1998, Ebert and Bunn 1998, Ema et al. 1999, Gu et al. 2001, Dames et al. 2002, Freedman et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
10202154	Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 Abe, H, Yodoi, J, Mimura, J, Hirota, K, Poellinger, L, Sogawa, K, Ema, M, Fujii-Kuriyama, Y	EMBO J	1999
11959990	Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha Livingston, DM, Freedman, SJ, Sun, ZY, Eck, MJ, Wagner, G, Kung, AL, Poy, F	Proc Natl Acad Sci U S A	2002
11959977	Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response De Guzman, RN, Dyson, HJ, Dames, SA, Wright, PE, Martinez-Yamout, M	Proc Natl Acad Sci U S A	2002
11063749	Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine Milligan, J, Gu, J, Huang, LE	J Biol Chem	2001
9822602	Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha Carrero, P, O'Brien, S, Poellinger, L, Kallio, PJ, Okamoto, K, Tanaka, H, Makino, Y	EMBO J	1998
17804822	The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha Chen, H, Simon, MC, Wang, L, Hu, CJ, Sataur, A	Mol Biol Cell	2007
9632793	Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein Ebert, BL, Bunn, HF	Mol Cell Biol	1998