Expression of HIGD1A

Stable Identifier
R-HSA-8932184
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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The HIGD1A (RCF1A, HIG1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Ameri et al. 2015). Expression of HIGD1A is transactivated by HIF in response to hypoxia (Ameri et al. 2015).

HIF binds the promoter of the HIGD1A gene and activates transcription (Ameri et al. 2015). In some cancer cell lines the HIGD1A promoter is methylated, preventing binding of HIF. Based on inferences from mouse homologs, HIF binds the HIGD1A promoter but its inducible expression is largely independent of the CBP/p300 CH1 domain, which interacts with HIF, (Kasper et al. 2005, Kasper and Brindle 2006) and the CBP/p300 holoproteins (Kasper et al. 2014).

Literature References
PubMed ID Title Journal Year
25683712 HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth

Ameri, K, Jahangiri, A, Maltepe, E, Sanders, TA, Nguyen, V, Aghi, MK, Rinaudo, PF, Pekmezci, M, Tormos, KV, Yeghiazarians, Y, Rajah, AM, Costello, JF, Nagarajan, R, Murphy, MP, Wheeler, ML, Jeffrey, SS

Cell Rep 2015
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