Expression of VEGFA

Stable Identifier
R-HSA-1235037
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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Expression of VEGFA
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The VEGFA (VEGF) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Hypoxia-inducible factor binds the VEGF promoter, recruits p300 and CBP, and enhances transcription.

Literature References
PubMed ID Title Journal Year
8756616 Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Semenza, GL, Agani, F, Forsythe, JA, Iyer, NV, Jiang, BH, Koos, RD, Leung, SW

Mol Cell Biol 1996
8917528 An essential role for p300/CBP in the cellular response to hypoxia

Livingston, DM, Goldberg, MA, Eckner, R, Jiang, C, Arany, Z, Huang, LE, Bhattacharya, S, Bunn, HF

Proc Natl Acad Sci U S A 1996
17804822 The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

Chen, H, Simon, MC, Wang, L, Hu, CJ, Sataur, A

Mol Biol Cell 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
HIF:CBP:p300 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-03-20)
Reviewed
Rantanen, K  (2012-05-19)
Created
May, B  (2011-03-21)
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