Expression of VEGFA

Stable Identifier
R-HSA-1235037
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The VEGFA (VEGF) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Hypoxia-inducible factor binds the VEGF promoter, recruits p300 and CBP, and enhances transcription.

Literature References
PubMed ID Title Journal Year
8917528 An essential role for p300/CBP in the cellular response to hypoxia

Arany, Z, Huang, LE, Eckner, R, Bhattacharya, S, Jiang, C, Goldberg, MA, Bunn, HF, Livingston, DM

Proc Natl Acad Sci U S A 1996
8756616 Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, JA, Jiang, BH, Iyer, NV, Agani, F, Leung, SW, Koos, RD, Semenza, GL

Mol Cell Biol 1996
17804822 The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

Hu, CJ, Sataur, A, Wang, L, Chen, H, Simon, MC

Mol Biol Cell 2007
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